Results 111 to 120 of about 225,576 (311)

LANDOWNER DECISION MAKING ABOUT RIPARIAN BUFFERS

open access: yes
A two-stage model is used to examine a landowner's decision to use riparian buffers. First, the farmer chooses whether to continue farming or to sell the land for development.
Lynch, Lori, Brown, Cheryl
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

High variation in Eastern Whip-poor-will home-range size and shape limits the effectiveness of one-size-fits-all habitat protection methods

open access: yesAvian Conservation and Ecology
Sustainable forestry harvest requires a balance between resource extraction and the habitat needs of wildlife. The breeding habitat of threatened birds is often delineated for protection by surveying sites for nesting pairs and applying fixed habitat ...
Alicia M Korpach   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Applying new regulatory criteria to protect riparian buffer zones

open access: yes, 2003
Proceedings of the 2003 Georgia Water Resources Conference, held April 23-24, 2003, at the University of Georgia.The Riparian Buffer Protection Program is one of the Upper Chattahoochee Riverkeeper’s primary initiatives for protecting water quality and
Champagne, Alice J. M., Boden, Darcie
core  

On a Station Buffer [PDF]

open access: yesProceedings of the Institution of Mechanical Engineers
n ...
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Modelling riparian buffers for water quality enhancement in the Karapiro catchment

open access: yes
The use of riparian land buffers is widely promoted as a method of mitigating the effects of sediment and nutrient runoff from intensive land use in New Zealand.
Marsh, Dan   +2 more
core  

Comparison of neighbourhood effects between relatively homogeneous buffers and all buffers together.

open access: yes, 2013
Comparison of neighbourhood effects between relatively homogeneous buffers and all buffers together.
Karien Stronks (76687)   +2 more
core   +1 more source

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