Results 131 to 140 of about 225,576 (311)

Malignant hyperthermia: to buffer or not to buffer

The Journal of Physiology, 2014
Meghna, Pant, Danesh H, Sopariwala, Naresh C, Bal   +2 more
openaire   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Intracellular and Extracellular buffers

, 2011
This RLO outlines the main intracellular and extracellular buffering systems within the body and shows how trhe carbonic acid buffering system can be ...

core  

Composition of electroporation buffers.

, 2016
Composition of electroporation buffers.
Olga N. Pakhomova (356382), Damijan Miklavčič (37188), Janja Dermol (3147795), Andrei G. Pakhomov (356389)   +3 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Conservation Buffers: Design Guidelines for Buffers, Corridors, and Greenways

, 2008
Conservation Buffers: Design Guidelines for Buffers, Corridors, and Greenways Over 80 illustrated design guidelines for conservation buffers are synthesized and developed from a review of over 1,400 research publications.
Bentrup, Gary
core  

DNA Strand Buffers

, 2018
A buffer reaction actively resists changes to the concentration of a chemical species. Typically, buffering reactions have only been able to regulate the concentration of hydronium (i.e., pH) and other ions.
Nisita Dutta (5738717), Dominic Scalise (3225543), Rebecca Schulman (652890), Dominic Scalise, Nisita Dutta, Rebecca Schulman   +5 more
core   +1 more source

Riparian forest buffer management in Norway: Evaluating adherence to certification standards

Trees, Forests and People
Riparian buffers are important for maintaining the ecological function of the riparian forest surrounding watercourses upon harvest. The Programme for the Endorsement of Forest Certification (PEFC), the world’s largest certification system by forest area,
Ane Christensen Tange, Hanne K. Sjølie
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Calibration of a solid-state copper ion-selective electrode in cupric ion buffers containing chloride

, 1991
It is shown that near-Nernstian calibration slopes can be obtained with a Cu1.8Se electrode in a range of cupric ion buffers in spite of a high chloride content. Best results are obtained with the ligands ethylenediamine, glycine and histidine. The onset
Boy Hoyer
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