Results 101 to 110 of about 3,025,553 (286)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Expansion and Acquisition: The Built Environment Under Gettysburg College President, Gordon Haaland, 1990 to 2004 [PDF]

open access: yes, 2019
Gordon Haaland presided over Gettysburg College from 1990 to 2004. His goals included improving the national status of the college by increasing the student body, developing the academic departments, and creating a dynamic campus community.
Labovitz, Hannah M., Shea, Lillian
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Mission Impracticable: The Impossibility of Commercial Impracticability [PDF]

open access: yes, 2015
[Excerpt] “Residents of Chicago’s Streeterville neighborhood certainly cannot forget the recent financial crisis thanks to a gaping hole in their midst.
Camero, Jennifer
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Material effects on strawbale wall seismic capacity [PDF]

open access: yes, 2017
Strawbale construction is a sustainable, viable alternative to conventional building practices. As a newly introduced appendix to the International Residential Code (IRC), the strawbale construction requirements may benefit from further evaluation and ...
Ackerson, Margaret, Williams, McKenna
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

THREE-DIMENSIONAL ANALYSIS FOR THE EFFECT OF PILES GEOMETRY AND ARRANGEMENT ON THE DYNAMIC RESPONSE OF PILED RAFT FOUNDATION

open access: yesJournal of Engineering and Sustainable Development, 2018
In the present study, three-dimensional analysis is presented to investigate the effect of pile dimensions and configuration on the dynamic response of piled raft foundations subjected to vertical vibration.
Mahmood Rashid Al-Qayssi   +2 more
doaj  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

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