Results 111 to 120 of about 709,095 (293)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

INVESTIGATING EFFECTS OF APPLICATION OF SILICA FUME AND SBS AS MODIFIERS TO REDUCE MOISTURE SENSITIVITY OF ASPHALT CONCRETE MIXTURE

Journal of Engineering and Sustainable Development, 2019
Moisture damage is one of the most common reasons for the premature deterioration of Hot Mix Asphalt (HMA) pavements. Over the years, extensive research has been carried out by scientists and engineers on this subject; however, pavements still succumb ...
Zaynab Ibrahim Qasim, Karim Hadi Ibrahim Al Helo, Sara Nadhim hameed   +2 more
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

GROUND WATER FLOW AND WATER BUDGET FOR THARTHAR LAKE

Journal of Engineering and Sustainable Development, 2017
Groundwater inflow to Tharthar lake and leakage from it, in time and space, were evaluated using hydrologic data and simulation model (Processing Modflow Pro) of the groundwater system adjacent to the lake. The temporal parameters include the time unit,
Thair Sharif Khayyun, Mustafa Majeed AbdulAaimma, Ahlam Sajir Mohamad   +2 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Modification of Pinhole Apparatus for Identification and Classification of Dispersive Clay Soils

Journal of Engineering and Sustainable Development, 2014
In this research, modification of the pinhole apparatus is made as required by the specification of the American Society for Testing and Materials (ASTM D4647 – 93)[3], which works on the basis that distilled water is passed horizontally under the ...
Mohammed Yousif Fattah, Hassan Ali Omran, Thabet Mohammed Abdulatif   +2 more
doaj  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Assessing the impact of amended building regulations on the operations of UK construction companies [PDF]

, 2008
The UK government continues to make regular amendments to building regulations. This is in order to keep these regulations relevant to today’s prevailing construction environment. More recently, UK building regulations have been amended to facilitate the
Ojiako, Udechukwu, Hughes, Lawrence, Dawson, Richard   +2 more
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Ohio State Office Building under construction

, 1931
Photograph of the partially-covered steel frame of the State Office (Ohio Departments of State) building, Columbus, ca. 1931-1932. Groundbreaking for the Ohio State Office Building took place on November 19, 1929.

core