Results 61 to 70 of about 308,019 (246)

The improved design method of shear strength of reinforced concrete beams without transverse reinforcement

Selected Scientific Papers: Journal of Civil Engineering, 2017
In this article, results of experimental testing of reinforced concrete beams without transverse shear reinforcement are given. Three prototypes for improved testing methods were tested.
Vegera Pavlo, Vashkevych Rostyslav, Khmil Roman, Blikharskyy Zinoviy   +3 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Effect of different buried depth on the disintegration characteristic of red-bed soft rock and the evolution model of disintegration breakage under cyclic drying-wetting

Scientific Reports
The disintegration of red-bed soft rock exhibits a strong correlation with various geological disasters. However, the investigation into the evolutionary mechanisms underlying disintegration breakage has not yet received extensive exploration.
Jun Zhang, Yang Guo, Kai Huang, Wei Cui, Zhaibang Ke, Xiaochuang Chen, Tengsheng Yue, Kun Gao   +7 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Large CO2 reduction and enhanced thermal performance of agro-forestry, construction and demolition waste based fly ash bricks for sustainable construction

Scientific Reports
The exhaust gases in production of burnt clay bricks is responsible for greenhouse gases (GHGs) emission which increase the carbon footprint in the ecosystem. Here, we report carbon emission and thermal performance based evaluation of 8 ft. × 9 ft.
Siddharth Singh, Soumitra Maiti, Ravindra Singh Bisht, Soraj Kumar Panigrahi, Sameer Yadav   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Methods for Dimensioning an Adhesive Joint for Use in Fluid-Filled Façade Element

Challenging Glass Conference Proceedings
Fluids in the cavity can be used to integrate additional functions into insulating glazing. However, the high permanent load exerted by the fluid on the glazing and surrounding components is problematic.
Alina Katzera, Michael Engelmann, Bernhard Weller   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

GS&E journal > Study on the optical quality and strength of glass edges after the grinding and polishing process

Challenging Glass Conference Proceedings, 2020
Glass edges result from cutting glass sheets and a further optional finishing. The mechanical interference into the brittle material glass causes flaws and cracks at the edge surface.
Paulina Bukieda, Katharina Lohr, Jens Meiberg, Bernhard Weller   +3 more
doaj