Results 81 to 90 of about 3,095,943 (305)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Building Materials and Construction: The Four Building Challenges

open access: yes, 2018
The chapter analyses the radical changes in the supply chain of building materials and construction between 1850 and 1910. It investigates the consequences for the four building challenges in this period: public hygiene, public housing, the struggle against water and the development of road infrastructure.
openaire   +2 more sources

Expansion and Acquisition: The Built Environment Under Gettysburg College President, Gordon Haaland, 1990 to 2004 [PDF]

open access: yes, 2019
Gordon Haaland presided over Gettysburg College from 1990 to 2004. His goals included improving the national status of the college by increasing the student body, developing the academic departments, and creating a dynamic campus community.
Labovitz, Hannah M., Shea, Lillian
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

The improved design method of shear strength of reinforced concrete beams without transverse reinforcement

open access: yesSelected Scientific Papers: Journal of Civil Engineering, 2017
In this article, results of experimental testing of reinforced concrete beams without transverse shear reinforcement are given. Three prototypes for improved testing methods were tested.
Vegera Pavlo   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Air-Entraining Effect on Rheological Properties of Cement-Based Mixtures

open access: yesAdvances in Materials Science and Engineering
The rheological properties and stability of cement-based materials determine the technological properties of concrete mixtures and significantly influence concrete properties.
Aigerim Tolegenova   +3 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Understanding Occupational and Skill Demand in New Jersey's Construction Industry [PDF]

open access: yes, 2005
The construction industry is integral to New Jersey's economy, employing over 160,000 people. Nationally and in New Jersey, the construction industry is thriving, injecting billions of dollars into the state.
Denise Pierson-Balik   +6 more
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

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