Results 71 to 80 of about 1,597,081 (316)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Building Data Citations for Discovery

, 2011
Authors who choose to cite the research data behind their published reports have a variety of options to entertain: domain style guides, publisher requirements, and data provider citation recommendations. Instructions from these sources may differ in terms of the range of required citation elements and guidance to authors on when and how research data ...
Hailey Mooney, Mark Newton
openaire   +3 more sources

Building information modeling and building automation systems data integration and big data analytics for building energy management

Title on author's file: BIM and BAS Data Integration and Big Data Analytics for Building Energy Management202407 bcchAccepted ManuscriptSelf-fundedPublishedGreen ...
Fan, C, Xiao, F
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Improving transparency in data access processes: Developing best practice standards and promoting system-wide change through a competitive funding call

International Journal of Population Data Science
Introduction Transparency in the use of data for research benefits the public and researchers by fostering trust and enabling efficient data sharing. Public support for access to their data for research depends on robust data security, the absence of ...
Yemi Macaulay, Ester Bellavia , Rachel Brophy, Angela Coulter, Ben Glampson, Bethany Gilbert, Alan Holcroft, Erik Mayer, Edel McNamara, Katherine O'Sullivan, Paola Quattroni, David Seymour, Yvonne Silove , Doreen Tembo, Andrew D Morris, Cassie Smith, Andy Boyd   +16 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Synthetic ALSPAC longitudinal datasets for the Big Data VR project [version 1; referees: 2 approved]

Wellcome Open Research, 2017
Three synthetic datasets - of observation size 15,000, 155,000 and 1,555,000 participants, respectively - were created by simulating eleven cardiac and anthropometric variables from nine collection ages of the ALSAPC birth cohort study.
Demetris Avraam, Rebecca C. Wilson, Paul Burton   +2 more
doaj   +1 more source

Adaptor Template Oligo-Mediated Sequencing (ATOM-Seq) is a new ultra-sensitive UMI-based NGS library preparation technology for use with cfDNA and cfRNA

Scientific Reports, 2021
Liquid biopsy testing utilising Next Generation Sequencing (NGS) is rapidly moving towards clinical adoption for personalised oncology. However, before NGS can fulfil its potential any novel testing approach must identify ways of reducing errors ...
Thomas L. Dunwell, Simon C. Dailey, Anine L. Ottestad, Jihang Yu, Philipp W. Becker, Sarah Scaife, Susan D. Richman, Henry M. Wood, Hayley Slaney, Daniel Bottomley, Xiangsheng Yang, Hui Xiao, Sissel G. F. Wahl, Bjørn H. Grønberg, Hongyan Dai, Guoliang Fu   +15 more
doaj   +1 more source

A diagnostic Bayesian network method to diagnose building energy performance

, 2019
In this paper the implementation of a diagnostic Bayesian network (DBN) method is presented which helps to overcome the problem that automated energy performance diagnosis in building energy management systems (BEMS) are seldom applied in practice ...
Itard, Laure, Corrado, Vincenzo, Zeiler, Wim, Gasparella, Andrea, Patuzzi, Francesco, Fabrizio, Enrico, Taal, Arie C.   +6 more
core   +1 more source