Results 91 to 100 of about 336,292 (314)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Estimation of Building Parameters Using Simplified Energy Balance Model and Metered Whole Building Energy Use [PDF]

, 2012
This paper presents and evaluates an indirect data-driven method to estimate influential building parameters: air exchange rates and overall heat transfer coefficients of building envelopes from the separately metered energy use for electricity, cooling ...
Masuda, H., Claridge, D.
core  

A diagnostic Bayesian network method to diagnose building energy performance

, 2019
In this paper the implementation of a diagnostic Bayesian network (DBN) method is presented which helps to overcome the problem that automated energy performance diagnosis in building energy management systems (BEMS) are seldom applied in practice ...
Itard, Laure, Corrado, Vincenzo, Zeiler, Wim, Gasparella, Andrea, Patuzzi, Francesco, Fabrizio, Enrico, Taal, Arie C.   +6 more
core   +1 more source

The application of predictive stochastic model based on Monte Carlo method in building energy saving renovation [PDF]

Archives of Civil Engineering
: This research has established an energy consumption prediction model based on the Monte Carlo method to resolve the energy-saving transformation problem. First, simplify the building to construct the proposed model.
Juxian Xiao
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Evidence-based calibration of a building energy simulation model: Application to an office building in Belgium [PDF]

, 2012
Energy services play a growing role in the control of energy consumption and the improvement of energy efficiency in non-residential buildings. This work consists in the application of a simulation-based approach dedicated to whole-building energy use ...
Randaxhe, François, Bertagnolio, S., Bertagnolio, Stéphane, Randaxhe, F., Lemort, V., Lemort, Vincent   +5 more
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Study of the Data Augmentation Approach for Building Energy Prediction beyond Historical Scenarios

, 2023
Building energy consumption predictive modeling using data-driven machine learning is currently highly prevalent. However, the model typically performs poorly when the predicted day’s energy consumption exceeds the upper bound of the historical ...
Haizhou Fang, Xiaolei Yuan, Haizhou, Fang, Tan, Hongwei, Kai Jiang, Hongwei Tan, Renrong Ding, Yuan, Xiaolei, Risto Kosonen, Kosonen, Risto, Jiang, Kai, Ding, Renrong   +11 more
core   +1 more source