Results 71 to 80 of about 2,095,399 (306)

Optimization Tools for Building Energy Model Calibration

Energy Procedia, 2017
Abstract Different optimization tools have been developed to find the best trade-off between competitive goals. The optimization problem is typical of the design process, where different design solutions have to be compared to achieve one or more objectives, often in contrast with each other.
Lara, Rigoberto Arambula, Naboni, Emanuele, Pernigotto, Giovanni, CAPPELLETTI, FRANCESCA, Zhang, Yi, Barzon, Furio, Gasparella, Andrea, ROMAGNONI, PIERCARLO   +7 more
openaire   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Identifying Key Parameters in Building Energy Models: Sensitivity Analysis Applied to Residential Typologies

Buildings
Building energy modeling tools play a crucial role in quantifying and understanding the energy performance of buildings. These tools require substantial amounts of data, which can be challenging to obtain and are often associated with significant ...
Sofía Gervaz, Federico Favre
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Solar Heat Gain Simulations for Energy-Efficient Guest Allocation in a Large Hotel Tower in Madrid

Buildings
The current climate and energy crises demand innovative approaches to operating buildings more sustainably. HVAC systems, which significantly contribute to a building’s energy consumption, have been a major focus of research aimed at improving ...
Iker Landa del Barrio, Markel Flores Iglesias, Juan Odriozola González, Víctor Fabregat, Jan L. Bruse   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The State of the Art of Residential Building Energy Retrofits in Libya and Neighbouring Mediterranean Countries: A Comprehensive Review

Energies
With the increasing concern about global warming and future climate change, attention has been drawn to the need to reduce building energy use through improving buildings’ energy efficiency.
Salwa Albarssi, Shan Shan Hou, Eshrar Latif   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Energy Demand Forecast Models for Commercial Buildings in South Korea

Energies, 2019
With the Paris Agreement entering into full force, South Korea must submit its target greenhouse gas emissions for commercial buildings by 2030 to the United Nations Framework Convention on Climate Change.
Sungkyun Ha, Sungho Tae, Rakhyun Kim
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source