Results 51 to 60 of about 336,292 (314)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Infiltration Models in EnergyPlus: Empirical Assessment for a Case Study in a Seven-Story Building

Buildings
The current decarbonization transition to be achieved by 2050 according to the European Council has given great prominence to the use of Digital Twins as tools for energy management.
Gabriela Bastos Porsani, María Fernández-Vigil Iglesias, Juan Bautista Echeverría Trueba, Carlos Fernández Bandera   +3 more
doaj   +1 more source

Development and Analysis of a Dynamic Energy Model of an Office Using a Building Management System (BMS) and Actual Measurement Data

Energies, 2021
Calibration of the energy model of a building is one of the essential tasks required to determine the efficiency of building management systems, and both their own and other systems’ improvement potential.
Rasa Džiugaitė-Tumėnienė, Rūta Mikučionienė, Giedrė Streckienė, Juozas Bielskus   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Real-Time Digital Twins for Building Energy Optimization Through Blind Control: Functional Mock-Up Units, Docker Container-Based Simulation, and Surrogate Models

Applied Sciences
The transition toward energy-efficient and smart buildings requires Digital Twins (DTs) that can couple real-time data with physics-based Building Energy Models (BEMs) for predictive and adaptive operation.
Cristina Nuevo-Gallardo, Iker Landa del Barrio, Markel Flores Iglesias, Juan B. Echeverría Trueba, Carlos Fernández Bandera   +4 more
doaj   +1 more source

Regional Building Energy Modelling: A Residential Building Stock Model for a Swedish Island

Energy and Buildings
This study presents the development and validation of a regional urban building energy model (UBEM) for the island of Gotland, Sweden, using openly available national datasets. The aim is to capture the diversity of the residential building stock-including both urban and rural areas-and provide a robust tool for large-scale energy planning and ...
Lukas Dahlström, Fatemeh Johari, Joakim Widén   +2 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The Diffusion of Energy Efficiency in Building

, 2011
We analyze the diffusion of buildings certified for energy efficiency across US property markets. Using a panel of 48 metropolitan areas (MSAs) observed over the last 15 years, we model the geographic patterns and dynamics of building certification ...
Nils Kok, McGraw, M., Quigley, J.M., Marquise McGraw, John M. Quigley, John M Quigley, Kok, N.   +6 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source