Results 41 to 50 of about 288,998 (266)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Real-Time Digital Twins for Building Energy Optimization Through Blind Control: Functional Mock-Up Units, Docker Container-Based Simulation, and Surrogate Models

Applied Sciences
The transition toward energy-efficient and smart buildings requires Digital Twins (DTs) that can couple real-time data with physics-based Building Energy Models (BEMs) for predictive and adaptive operation.
Cristina Nuevo-Gallardo, Iker Landa del Barrio, Markel Flores Iglesias, Juan B. Echeverría Trueba, Carlos Fernández Bandera   +4 more
doaj   +1 more source

Development and Analysis of a Dynamic Energy Model of an Office Using a Building Management System (BMS) and Actual Measurement Data

Energies, 2021
Calibration of the energy model of a building is one of the essential tasks required to determine the efficiency of building management systems, and both their own and other systems’ improvement potential.
Rasa Džiugaitė-Tumėnienė, Rūta Mikučionienė, Giedrė Streckienė, Juozas Bielskus   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Construction of Building Energy Consumption Prediction Model Based on Multi-Optimization Model

Buildings, 2023
This study explores the utilization of the Relevance Vector Machine (RVM) model, optimized using the Sparrow Search Algorithm (SSA), Simulate Anneal Arithmetic (SAA), Particle Swarm Optimization (PSO), and Bayesian Optimization Algorithm (BOP), to ...
Hongyan Wang, Wen Wen, Zihong Zhang, Ning Gao   +3 more
doaj   +1 more source

Regional Building Energy Modelling: A Residential Building Stock Model for a Swedish Island

Energy and Buildings
This study presents the development and validation of a regional urban building energy model (UBEM) for the island of Gotland, Sweden, using openly available national datasets. The aim is to capture the diversity of the residential building stock-including both urban and rural areas-and provide a robust tool for large-scale energy planning and ...
Lukas Dahlström, Fatemeh Johari, Joakim Widén   +2 more
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Data-Driven Building Energy Consumption Prediction Model Based on VMD-SA-DBN

Mathematics, 2022
Prediction of building energy consumption using mathematical modeling is crucial for improving the efficiency of building energy utilization, assisting in building energy consumption planning and scheduling, and further achieving the goal of energy ...
Yongrui Qin, Meng Zhao, Qingcheng Lin, Xuefeng Li, Jing Ji   +4 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source