Results 81 to 90 of about 336,292 (314)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Building Energy Benchmarking for Retrofit: An Application of Normative Building Modeling
, 2012 Normative building modeling, addressed in ISO 13790 (Thermal performance of buildings-Calculations of energy use for space heating), has been adopted in major European countries in various applications, including building energy certificate and energy ...
Johnson, Nicolas Robert, Hu, Huafen
core
THERMAL MODEL OF ENERGY EFFICIENT BUILDING
Informatika, 2016 Thermal 3-D model of a rural area building is proposed. The model includes constructive, finite element, analytical and computational models which are created using SolidWorks software (constructive model) and COMSOL Multiphysics software (finite element,
E. V. Kresova, S. P. Kundas
doaj
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Model Code for Energy Conservation in New Building Construction
, 1977 76 pagesIn response to the recognized lack of existing consensus standards directed to the conservation of energy in building design and operation, the preparation and publication of such a standard was accomplished with the issuance of ASHRAE Standard ...
Southern Building Code Congress International, Inc. +2 more
core
Hybrid Model of Existing Buildings for Transient Thermal Performance Estimation [PDF]
, 2006 Building level energy models are important to provide accurate prediction of energy consumption for building performance diagnosis and energy efficiency assessment of retrofitting alternatives for building performance upgrading. Simplified but physically
Wang, S., Xu, X., Wang, SW, Xu, XH
core
A ducted wind turbine simulation model for building simulation
, 2004 Power production is shifting away from centralized generation plants to production of heat and power at the point of demand. A technology that may play a part in this shift is the ducted wind turbine (DWT).
Kelly, N.J., Grant, A.D.
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Development and performance assessment of a new opensource Bayesian inference R platform for building energy model calibration. [PDF]
Discov Mech Eng, 2023 Hou D +4 more
europepmc +1 more source