Results 51 to 60 of about 15,698,609 (248)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Comparison of a Solar Driven Absorption Chiller and Photovoltaic Compression Chiller Under Different Demand Profiles: Technological, Environmental and Economic Performance

Energies
HVAC systems are becoming increasingly important around the world due to the increasing need for climatization in recent years. While district heating systems have been used for a long time, district cooling systems tend to be something that is only ...
Juan José Roncal-Casano, Javier Rodríguez-Martín, Paolo Taddeo, Javier Muñoz-Antón, Alberto Abánades-Velasco   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Determining retrofit technologies for building energy performance

Journal of Asian Architecture and Building Engineering, 2020
Worldwide, the building sector is responsible for consuming more than 36% of the final global energy and produces 39% of carbon dioxide emissions. Accordingly, sustainable retrofit is an important method to achieve energy reduction and sustainable ...
Bianca-Elena Benzar, Moonseo Park, Hyun-Soo Lee, Inseok Yoon, Jongwoo Cho   +4 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Reducing Building Energy Performance Gap: Integrating Agent-Based Modelling and Building Performance Simulation

Buildings
The building energy performance gap (BEPG) remains a significant challenge, undermining the accuracy of energy simulations and complicating efforts to design energy-efficient buildings.
Chi-Li Chiang, John Calautit
doaj   +1 more source

Energy Performance Indices for Hospital Buildings in Nigeria

International Journal of Technology, 2016
In Nigeria, the economic problem of allocating energy to medicare have long been a major concern and standardized indices to be used as guidance are non-existent. This paper determines energy indices for assessment of how Nigerian hospitals prioritize
S.C. Nwanya, C. Sam Amobi, O.V. Ekechukwu   +2 more
doaj   +1 more source