Results 81 to 90 of about 15,698,609 (248)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Zone-wise occupancy schedules developed using Time Use Survey data for building energy performance simulations. [PDF]

Data Brief, 2023
Sood D, Alhindawi I, Ali U, Finn D, McGrath JA, Byrne MA, O'Donnell J.   +6 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Applying modified coot optimization algorithm with artificial neural network meta-model for building energy performance optimization: A case study. [PDF]

Heliyon, 2023
You X, Yan G, Thwin M.
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Building performance optimization of net zero-energy buildings

, 2015
Building performance optimization (BPO) paired with building performance simulation (BPS) is a promising solution for evaluating many different design options and obtaining the optimal or near-optimal solution for a given objective or combination of ...
Pagliano, L., Hamdy, M., Bucking, S., Carlucci, S., O'Brien, W., Attia, S.G., Hasan, A., Athienitis, A.   +7 more
core   +1 more source

Calibrated Physics-Based Dynamic Energy Modelling of an Airport Terminal

Buildings
This study developed a calibrated, data-supported energy simulation model for the Arrivals Terminal of Cluj-Napoca International Airport (Romania), addressing challenges in modelling complex building typologies.
Ancuța Maria Măgurean, Dan Doru Micu
doaj   +1 more source

Mind the Energy Performance Gap: testing the accuracy of building Energy Performance Certificates in Ireland. [PDF]

Energy Effic, 2021
Coyne B, Denny E.
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Application of CFD in building performance simulation for the outdoor environment

, 2009
This paper provides a brief, non-exhaustive overview of the status of the application of CFD in building performance simulation for the outdoor environment. It focuses on four topics: (1) pedestrian wind environment around buildings; (2) wind-driven rain
Blocken, B.J.E., Kelly, N.J., Hensen, J.L.M., Carmeliet, J.E., Strachan, P.A., Kummert, M., Stathopoulos, T.   +6 more
core