Results 131 to 140 of about 132,806 (311)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Exploring the effectiveness of Building Performance Codes: A Lighting Standard Case Study

, 2016
A multitude of international and national standards aim at ensuring transparence and accountability with regard to building performance criteria. However, there are few studies that address the effectiveness of these standards in view of building design ...
Manescu, Elisabeta-Monica, Pont, Ulrich, Mahdavi, Ardeshir   +2 more
core  

Interpenetrated Robust Metal–Organic Framework with Urea-Functionality-Decked Pores for Selective and Ultrasensitive Detection of Antibiotics and Oxo-anions

Conjoining the benefits of structural diversity and deliberate implantation of task-specific sites inside the porous channels, metal–organic frameworks (MOFs) not only ensure environmental remediation via acute detection of organic as well as inorganic ...
Renjith S. Pillai (2291182), Shifna K. P. Fathima (17120088), Partha Pratim Mondal (17120085), Devaraj Muthukumar (14000869), Subhadip Neogi (1776325)   +4 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A Review Informed Translation Framework for Mapping Smart Building Services into Smart Readiness Indicator Aligned Assessment

Buildings
Smart building services are increasingly realised through combinations of sensors, actuators, communication infrastructures, software platforms, analytics, and artificial intelligence-based functions.
Bo Nørregaard Jørgensen, Benjamin Eichler Staugaard, Simon Soele Madsen, Zheng Grace Ma   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Community-level post-hazard functionality methodology for buildings exposed to floods

This paper presents a building-level post-hazard functionality model for communities exposed to flood hazards including the interdependencies between the population, buildings, and infrastructure.
Cha, Eun Jeong, Cutler, Harvey, Nofal, Omar, Endrami, Amin, Sutley, Elaina, Patil, Jayant, Jeon, Hwayoung, Kameshwar, Sabarethinam, Rosenheim, Nathanael, van de Lindt, John W., Duenas-Osorio, Leonardo, Lu, Tao, Wang, Chen, Zhou, Xiangnan   +13 more
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

A novel DSM philosophy for building integrated renewable systems

, 2011
This paper presents an overview of a novel concept in IT network design and power control focused on matching building integrated renewable power generation with local demands.
Stewart, Matt John, Logan, Rufus, Ward, Wayne, Doran, Sean, Counsell, John   +4 more
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source