Results 111 to 120 of about 132,806 (311)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Quality Assessment of Interactive Mobile Application – Maternal and Infant Care for Tribal Birth Attendants

Indian Journal of Public Health
Digital health interventions can overcome geographical barriers and prepare health-care providers for better health outcomes in rural and remote tribal areas, however, it has not been explored among traditional birth attendants (TBAs).
Rakhi Dwivedi, Akhil Dhanesh Goel, Varuna Vyas, Prem Prakash Sharma, Pratibha Singh, Kuldeep Singh   +5 more
doaj   +1 more source

Applying the KISS principle for the CLEF-IP 2010 prior art candidate patent search task [PDF]

, 2010
We present our experiments and results for the DCU CNGL participation in the CLEF-IP 2010 Candidate Patent Search Task. Our work applied standard information retrieval (IR) techniques to patent search.
Magdy, Walid, Jones, Gareth J.F.
core  

A Reprise, Or Round Three: Using a Database Management Program as a Decision-Support System for the Cancellation of Serials

, 2009
Annual journal inflation rates of eight percent or higher have compelled libraries to cancel journals. Since 1992 Purdue Libraries have had three major cancellation projects.
Judith M. Nixon, Nixon, Judith M.
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The functionality of patriotism in nation-building in Uganda

, 2023
A research paper submitted in partial fulfillment of the requirements for the award of the degree of Master of Security Strategy of Makerere UniversityThis research paper explored the functionality of patriotism in nation-building in Uganda.
Byekwaso, Flavia
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Early Roman Finds from Acic Suat (Caraburun, Baia, Tulcea County) [PDF]

Peuce, 2017
This paper presents some preliminary results of the study of the pottery finds found in an early Roman building discovered in the settlement at Acic Suat (Caraburun, com. Baia, Tulcea county), in the 2015 campaign.
Alina MUŞAT-STREINU
doaj  

Omega-Psir: From the Repository to the Research Knowledge Base Experience of Warsaw University of Technology

Foundations of Management, 2013
This paper is devoted to a solution for building a research knowledge base for the university. An experience in developing a specialised software for building such a knowledge base is presented.
Rybiński Henryk, Koperwas Jakub, Skonieczny Łukasz, Kozłowski Marek, Kozłowski Marek   +4 more
doaj   +1 more source