Results 101 to 110 of about 132,806 (311)

Beyond Functionality: Building Value To Essential Oils Products at Indonesia Digital Market Field

open access: yesIndonesian Journal of Business and Entrepreneurship
Background: This study investigates the evolving online marketing skills in the digital marketplace, focusing on essential oil products. These products often face market uncertainty regarding product attribute value.
Zainur Romli
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Functionality-Independent Style-Based Procedural Building Generation

open access: yes, 2017
In computer graphics it is often necessary to construct a large number of objectsof specific types, such as buildings. One approach is to create the models procedurally,an approach that often renders function and appearance tightly coupled.
Pessa, Mikael
core  

Multi-functionality building - Sammontalo [PDF]

open access: yes, 2019
In comprehensive-school stage of life, pupils need to be prepared, basically, knowledge and social integration for life later on. Pedagogy of imparting knowledge have long history of reforming, nowadays, study program have being gradually blurred ...
Le, Hoai
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Energetic and Functional Upgrading of School Buildings

open access: yes, 2016
In Italy, currently most schools require improvements to energy performance and indoor air quality. On the other hand, school buildings require structural assessment and strong renovation interventions to maintain their service functionality. Moreover, the use of spaces should be reviewed and redesigned to be more compatible with modern educational ...
Giordani, Paolo   +5 more
openaire   +2 more sources

Automated checking of building component accessibility for maintenance

open access: yes, 2020
Maintainability is not traditionally considered in the design of buildings. This is partly because design tools seldom facilitate the involvement of facility managers. They do not have rules for checking maintainability either.
Akanmu, Abiola A.   +2 more
core   +1 more source

Co-simulation of building energy simulation and computational fluid dynamics for whole-building heat, air and moisture engineering [PDF]

open access: yes, 2011
Building performance simulation (BPS) is widely applied to analyse heat, air and moisture (HAM) related issues in the indoor environment such as energy consumption, thermal comfort, condensation and mould growth.
Mirsadeghi, M Mohammad, Mirsadeghi, M.
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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