Results 121 to 130 of about 3,099,998 (314)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

A Design for Safety (DFS) Framework for Automated Inspection Risks in Metro Stations by Integrating a Knowledge Base and Building Information Modeling. [PDF]

Int J Environ Res Public Health, 2023
Liu P, Shang Y, Zhang L.
europepmc   +1 more source

Development of a Bridge Management System Based on the Building Information Modeling Technology

Sustainability, 2019
With the development of the Chinese transportation industry, the number of bridges has increased significantly, but this results in high pressure of structural maintenance and management.
C. Wan, Zhenwei Zhou, Siyuan Li, You-liang Ding, Zhao Xu, Zegang Yang, Yefei Xia, F. Yin   +7 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Enhancing Building Energy Efficiency through Building Information Modeling (BIM) and Building Energy Modeling (BEM) Integration: A Systematic Review

Buildings
With the ever-increasing population and historic highest energy demand, the energy efficiency of buildings is becoming crucial. Architectural firms are moving from traditional Computer-Aided Design (CAD) to BIM.
Mohammed Alhammad, Matt Eames, Raffaele Vinai   +2 more
doaj   +1 more source

Evaluation and selection of the quality of internal doors for buildings using building information modeling building information modeling (BIM)

, 2021
Ibrahim Al-Hammad, Zaidan Ahmed Zanklo
openalex   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Enhancing Interoperability Between Building Information Modeling and Building Energy Modeling: Alphanumerical Information Exchange for Energy Optimization in Early Design Stages

Applied Sciences
Building information modeling (BIM) has revolutionized integrated planning by optimizing costs, schedule, and material use. However, building energy modeling (BEM) remains underutilized in early design stages due to interoperability challenges between ...
Josef Miller, Larissa Schneiderbauer, Martin Hauer, Alexandra Jäger, Georg Fröch, Rainer Pfluger, Stephan Moser   +6 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source