Results 101 to 110 of about 241,946 (291)

An integrated framework for engaging stakeholders in the circular economy processes using Building Information Modeling and virtual reality [PDF]

open access: yes, 2023
Global climate change has become increasingly problematic over the past few decades. The construction industry has contributed to greenhouse gas emissions in recent decades.
Lendinez, Francisco   +2 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Structure–Function Relationship in Citrus-Fiber-Based Emulgels for Controlled Curcumin Delivery

open access: yesGels
Biphasic systems able to effectively release bioactive molecules along the gastrointestinal tract (GIT) are receiving growing interest. In this work, emulgels structured with citrus fiber, a digestion-resistant structuring agent, were produced using two ...
Domenico Mammolenti   +4 more
doaj   +1 more source

Building Information Modeling BIM - Level of Digital Construction

open access: yesArchives of Civil Engineering, 2017
In the paper the topic of Building Information Technology BIM is investigated. It is new in Polish circumstances technology for construction and for building product industry, which contribute to change and develop level of industrialization.
Glema A.
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Enhancing Building Energy Efficiency through Building Information Modeling (BIM) and Building Energy Modeling (BEM) Integration: A Systematic Review

open access: yesBuildings
With the ever-increasing population and historic highest energy demand, the energy efficiency of buildings is becoming crucial. Architectural firms are moving from traditional Computer-Aided Design (CAD) to BIM.
Mohammed Alhammad   +2 more
doaj   +1 more source

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