Results 81 to 90 of about 214,441 (246)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Building Information Modeling

open access: yes, 2019
N ...
Herbert W. Stanford, Adam F. Spach
openaire   +3 more sources

Structure–Function Relationship in Citrus-Fiber-Based Emulgels for Controlled Curcumin Delivery

open access: yesGels
Biphasic systems able to effectively release bioactive molecules along the gastrointestinal tract (GIT) are receiving growing interest. In this work, emulgels structured with citrus fiber, a digestion-resistant structuring agent, were produced using two ...
Domenico Mammolenti   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Enhancing Building Energy Efficiency through Building Information Modeling (BIM) and Building Energy Modeling (BEM) Integration: A Systematic Review

open access: yesBuildings
With the ever-increasing population and historic highest energy demand, the energy efficiency of buildings is becoming crucial. Architectural firms are moving from traditional Computer-Aided Design (CAD) to BIM.
Mohammed Alhammad   +2 more
doaj   +1 more source

Um jogo de tabuleiro para o processo de ensino-aprendizagem de projeto colaborativo em building information modeling

open access: yesOculum Ensaios, 2023
A obrigatoriedade do Building Information Modeling no Brasil teve início em 2021, quando entrou em vigor a primeira meta da Estratégia Building Information Modeling Brasil, onde toda obra pública do Governo Federal deve ter seu projeto apresentado em ...
Roberto Cavalleiro de Macedo Alves   +1 more
doaj  

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