Results 81 to 90 of about 1,400,684 (280)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
BuildingsThe conversion from building information modeling (BIM) to building energy modeling (BEM) based on the industry foundation classes (IFC) data standard is a crucial step for efficient building energy design and energy performance analysis.
Na An +5 more
doaj +1 more source
Conceptual Framework for the Use of Building Information Modeling in Engineering Education [PDF]
, 2019 The objective of this paper is to present a critical literature review of the Building Information Modelling (BIM) methodologyandtoanalyzewhetherBIMcanbeconsideredaVirtualLearningEnvironment.Aconceptualframeworkis proposed for using BIM in a university ...
Aguayo-González, Francisco +3 more
core
Engineering Resilient Collective Adaptive Systems by Self-Stabilisation [PDF]
, 2017 Collective adaptive systems are an emerging class of networked computational systems, particularly suited in application domains such as smart cities, complex sensor networks, and the Internet of Things.
Audrito, Giorgio +4 more
core +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Pushing architectural quality further [PDF]
, 2008 In this paper, the intentions thriving the implementation of computational modeling of building physics as it is approached in the Architectural engineering courses at Ghent University are discussed.
Janssens, Arnold +2 more
core
Construction safety and digital design: a review [PDF]
, 2012 As digital technologies become widely used in designing buildings and infrastructure, questions arise about their impacts on construction safety. This review explores relationships between construction safety and digital design practices with the aim ...
Sacks, Rafael +2 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Bibliometric Maps of BIM and BIM in Universities: A Comparative Analysis [PDF]
, 2019 Building Information Modeling (BIM) is increasingly important in the architecture and engineering fields, and especially in the field of sustainability through the study of energy.
Aish +15 more
core +2 more sources