Results 121 to 130 of about 907,023 (287)

Extension of Petri Nets by Aspects to Apply the Model Driven Architecture Approach [PDF]

open access: yes, 2005
Within MDA models are usually created in the UML. However, one may prefer to\ud use different notations such as Petri-nets, for example, for modelling concurrency\ud and synchronization properties of systems. This paper claims that techniques that\ud are
Aksit, M., Roubtsova, E.E.
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Sustainable facilities management through building information modelling [PDF]

open access: yes, 2014
Building Information Modelling (BIM) is an approach to improving the efficiency of the building process and potentially providing the key data set needed by facilities managers to operate buildings in a more sustainable manner.
Carbonari, Giulia, Jones, Keith
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Distributed Information Management with Mobile Agents

open access: yes, 1997
With more users taking advantage of publicly accessible networks, such as corporate intranets and the Internet, larger amounts of information is becoming electronically distributed and disseminated.
Dale, Jonathan, DeRoure, David C.
core  

Bridging the Gap between Enumerative and Symbolic Model Checkers [PDF]

open access: yes, 2009
We present a method to perform symbolic state space generation for languages with existing enumerative state generators. The method is largely independent from the chosen modelling language.
Blom, Stefan   +2 more
core   +3 more sources

Non-uniform state space reconstruction and coupling detection

open access: yes, 2010
We investigate the state space reconstruction from multiple time series derived from continuous and discrete systems and propose a method for building embedding vectors progressively using information measure criteria regarding past, current and future ...
Kugiumtzis, Dimitris, Vlachos, Ioannis
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

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