Results 121 to 130 of about 754,439 (266)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Model Transformation from SimModel to Modelica for Building Energy Performance Simulation

, 2019
BauSIM2014: 5th German-Austrian Conference of the International Building Performance Simulation Association, Aachen University, Germany, 22-24 September 2014This paper demonstrates a model transformation tool between the Building Information Model (BIM ...
O'Donnell, James, Maile, Tobias, Cao, Jun, et al., O\u27Donnell, James   +4 more
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Architect Friendly: a Comparison of Ten Different Building Performance Simulation Tools [PDF]

, 2009
Performance Simulation tools BPS is available internationally. The users of those tools are mainly researchers, physicists and experts who value empirical validation, analytical verification and calibration of uncertainty as defined by e.g.
J. Hensen, Attia, Shady, Attia, Shady Galal Mohamed, De Herde, A., L. Beltrán, Beltrán, Liliana, Hensen, JLM Jan, Beltran, L., S. Attia, A. De Herde, Attia, SG, Hensen, J.L.M., De Herde, André, Beltran, L, Hensen, Jan, Hensen, Jan LM, Attia, S.G., De Herde, A   +17 more
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Numerical analysis of the performance of a venturi-shaped roof for natural ventilation : influence of building width

, 2012
A numerical analysis with Computational Fluid Dynamics (CFD) is performed to investigate the influence of building width on the performance of a venturi-shaped roof (called Ventec roof) for natural ventilation. The specific roof configuration is intended
Blocken, B.J.E., Bronsema, B, van Hooff, T., van Hooff, T.; id_orcid, Blocken, BJE Bert, Aanen, L., Bronsema, B., Hooff, TAJ Twan van, Aanen, L, Blocken, B.; id_orcid   +9 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Building performance optimization of net zero-energy buildings

, 2015
Building performance optimization (BPO) paired with building performance simulation (BPS) is a promising solution for evaluating many different design options and obtaining the optimal or near-optimal solution for a given objective or combination of ...
Pagliano, L., Hamdy, M., Bucking, S., Carlucci, S., O'Brien, W., Attia, S.G., Hasan, A., Athienitis, A.   +7 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A machine learning algorithm to improve building performance modeling during design. [PDF]

MethodsX, 2020
Chokwitthaya C, Zhu Y, Dibiano R, Mukhopadhyay S.   +3 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

An implementation of co-simulation for performance prediction of innovative integrated HVAC systems in buildings [PDF]

, 2009
Integrated performance simulation of buildings and heating, ventilation and air-conditioning (HVAC) systems can help reducing energy consumption and increasing level of occupant comfort. However, no singe building performance simulation (BPS) tool offers
Hensen, Jan L. M., Trcka, M Marija, Wetter, M., Hensen, J.L.M., Trcka, M., Trcka, Marija, Wetter, M, Hensen, JLM Jan, Wetter, Michael   +8 more
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