Results 131 to 140 of about 754,439 (266)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Gap theory based post-occupancy evaluation (GTbPOE) of dormitory building performance: A case study and a comparative analysis. [PDF]

Build Environ, 2020
Hou HC, Lai JHK, Edwards D.
europepmc   +1 more source

Implementation and demonstration of a building simulation based testbed for assessment of data centre multi-domain control strategies

, 2017
The traditional data centre (DC) infrastructure is being significantly extended by modern information technology (IT) trends on one side, and lasting calling for DC sustainability on the other.
Hensen, J.L.M., Wetter, M., Zavrel, V., Torrens Galdiz, J.I., Barnaby, C.S.   +4 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Artificial Intelligence and Digital Twins for Bioclimatic Building Design: Innovations in Sustainability and Efficiency

Energies
The integration of artificial intelligence (AI) into bioclimatic building design is reshaping the architecture, engineering, and construction (AEC) industry by addressing critical challenges in sustainability and efficiency.
Ekaterina Filippova, Sattar Hedayat, Tina Ziarati, Matteo Manganelli   +3 more
doaj   +1 more source

The use of finite-element software to solve hygrothermal builiding physical problems related to insultating high rise buildings facades

, 2008
In The Netherlands high rise buildings from 1960 and before were hardly insulated. To improve the thermal performance of the buildings the facades may be insulated afterwards. The energy loss will be reduced and thermal comfort will be improved by higher
Schellen, H.L., Neuhaus, E., Hensen, Jan, Schijndel, van, A.W.M.   +3 more
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Simulation and the building performance gap

Buildings & Cities
Highlights This special collection examines simulation and the building performance gap. It focuses on quality assurance measures, case studies, user studies that address the development of trust in the performance calculations of designers.
Michael Donn
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Towards more effective use of building performance simulation in design

, 2004
This paper discusses some issues which hinder effective use of building performance simulation in building design, and some approaches towards better and more efficient use of this important but underutilized technology.
Timmermans, H.J.P., Hensen, J.L.M., Leeuwen, van, J.P.   +2 more
core