Results 141 to 150 of about 754,439 (266)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Air and heat flow through large vertical openings

, 1993
After a short description of the physical phenomena involved, unified expressions are worked out describing net airflow and net heat flow through large vertical openings between stratified zones.
Roos, A de, Hensen, J.L.M., Roos, A., Roos, A, Maas, J.H., Maas, JH, Roos, de, A., Hensen, JLM Jan   +7 more
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Computational Fluid Dynamics simulations of wind-driven rain on a low-rise building : new validation efforts [PDF]

, 2005
Despite the establishment of CFD as a tool for calculating the amount of wind-driven rain (WDR) falling onto building facades, very few efforts have been made towards the validation of CFD for this purpose.
Blocken, B.J.E., Carmeliet, J., Blocken, BJE Bert, Carmeliet, JE Jan   +3 more
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Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

O simulaciji karakteristika zgrade u promenljivoj zivotnoj sredini = On building performance simulation in a changing environment [PDF]

, 2007
[On building performance simulation in a changing environment] Computational simulation is one of the most powerful tools in our world today - it is used to simulate everything from war to economic growth.
Hensen, J.L.M., Hensen, JLM Jan
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Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Application of externally-coupled BES-CFD in HAM engineering of the indoor environment

, 2009
The high importance of indoor environment performance aspects such as surface condensation, mold growth, thermal comfort, etc., is widely recognized.
Blocken, B.J.E., Kelly, N.J., Hensen, J.L.M., Strachan, P.A., Kummert, M., Mirsadeghi, M.   +5 more
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Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Joining forces in building energy simulation

, 1993
As a result of the progression of computing power and the increasing demands for detailed thermal performance assessment users are shifting from simplified design tools to comprehensive, dynamic thermal appraisal tools which are able to handle the ...
Hensen, J.L.M., Clarke, JA, Strachan, P., Strachan, P, Hand, JW, Clarke, J.A., Hand, J.W., Hensen, JLM Jan   +7 more
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Dynamic sensitivity analysis for performance-based building design and operation [PDF]

, 2013
This paper presents dynamic sensitivity analysis as a novel design analysis tool for dealing with timevarying performance aspects in the built environment.
Loonen, R.C.G.M., Hensen, J.L.M., Loonen, R.C.G.M.; id_orcid, Loonen, RCGM Roel, Hensen, JLM Jan   +4 more
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