Results 81 to 90 of about 754,439 (266)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

The Evaluation of Building’s Structural Reliability of Masjid Tuha Indrapuri, Aceh Besar

open access: yesElkawnie: Journal of Islamic Science and Technology, 2019
Masjid Tuha Indrapuri is one the ancient mosques in Aceh located in the district of Aceh Besar. The precise location of the mosque is in Indrapuri, Aceh Besar. Masjid Tuha Indrapuri exists right in the complex of the former temple.
Riza Aulia Putra, Saiful Hadi
doaj   +1 more source

Computer simulation for better design and operation of large office building air-conditioning [PDF]

open access: yes, 2009
The paper deals with the use of computer simulations both for the design support of a new buildings and HVAC system development and for the optimisation of the system control strategy in the building. This is presented on a real office building in Prague.
Lain, M Milos   +6 more
core  

Gaussian-Process-Based Emulators for Building Performance Simulation [PDF]

open access: yes
In this paper we present a novel emulator of a building simulator for the simulation-assisted design of high performance buildings. Our emulator is based on Gaussian-Process (GP) regression models.
Khan, Mohammad Emtiyaz   +2 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Evaluation of reinforced concrete structural durability in the post-occupation phase - A case study in Novo Hamburgo/RS

open access: yesREM: International Engineering Journal
Researches on building performance have been developed over time. The Brazilian Performance Standard - NBR 15575 - deals with the issues of durability applied to residential buildings, establishing criteria and parameters to classify the systems into ...
Guilherme Manfredini Bueno   +4 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Effective interdisciplinary stakeholder engagement in net zero building design

open access: yesBuildings & Cities
Stakeholder engagement is crucial to the design and construction stages of net zero buildings, requiring interdisciplinary collaboration to promote the integrated design process.
Simon Vakeva-Baird   +3 more
doaj   +1 more source

Relation between design requirements and building performance simulation [PDF]

open access: yes, 2006
The aim of this paper is to reveal the relation between basic design requirements and the use of building performance simulation in current design practice.
Struck, C.   +7 more
core  

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