Results 81 to 90 of about 11,576,501 (264)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Integration of control and building performance simulation software by run-time coupling

, 2003
This paper presents the background, approach and initial results of a project, which aims to achieve better integrated building and systems control modeling in building performance simulation by runtime coupling of distributed computer programs.
Soethout, L.L., Hensen, J., Hensen, J.L.M., Jan Hensen, Yahiaoui, A., Yahiaoui, A Azzedine, Azzedine Yahiaoui, Luc Soethout, Hensen, JLM Jan, Soethout, LL   +9 more
core  

Computer simulation for better design and operation of large office building air-conditioning [PDF]

, 2009
The paper deals with the use of computer simulations both for the design support of a new buildings and HVAC system development and for the optimisation of the system control strategy in the building. This is presented on a real office building in Prague.
Lain, M Milos, Hensen, J., Hensen, J.L.M., Zmrhal, V, Lain, M., Hensen, JLM Jan, Zmrhal, V.   +6 more
core   +1 more source

Biophilic Design and Climate Change: Performance Parameters for Health

Frontiers in Built Environment, 2019
Biophilic design is one of a number of trending design practices that rely on nature-based systems, engineering principles and design cues to improve environmental quality, health, and efficiency.
Julia Africa, Judith Heerwagen, Vivian Loftness, Catherine Ryan Balagtas   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Building performance simulations can inform IoT privacy leaks in buildings. [PDF]

Sci Rep, 2023
Wang A, Campbell B, Heydarian A.
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Effective interdisciplinary stakeholder engagement in net zero building design

Buildings & Cities
Stakeholder engagement is crucial to the design and construction stages of net zero buildings, requiring interdisciplinary collaboration to promote the integrated design process.
Simon Vakeva-Baird, Farhang Tahmasebi, Joe-Jack Williams, Dejan Mumovic   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Relation between design requirements and building performance simulation [PDF]

, 2006
The aim of this paper is to reveal the relation between basic design requirements and the use of building performance simulation in current design practice.
Struck, C., Struck, C Christian, Ulukavak Harputlugil, G., Hopfe, C.J., Hensen, J.L.M., Harputlugil, GU, Hopfe, CJ Christina, Hensen, JLM Jan   +7 more
core   +1 more source