Results 31 to 40 of about 102,563 (261)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
How to Conduct Human-Centric Building Design? A Review of Occupant Modeling Methods and Applications
BuildingsOccupant modeling has emerged as a critical component in human-centric building design and operation, offering detailed insights into energy performance, comfort optimization, and behavior-driven control strategies.
Rui Sun +4 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Calibrated Physics-Based Dynamic Energy Modelling of an Airport Terminal
BuildingsThis study developed a calibrated, data-supported energy simulation model for the Arrivals Terminal of Cluj-Napoca International Airport (Romania), addressing challenges in modelling complex building typologies.
Ancuța Maria Măgurean, Dan Doru Micu
doaj +1 more source
A Strategy to Maximally Utilize Outdoor Air for Indoor Thermal Environment
Energies, 2021 In order to reduce the energy consumption of HVAC systems in buildings, the use of energy-saving solutions is necessary. One of these solutions is ventilation, which is usually used for maintaining acceptable indoor air quality and thermal comfort.
Lei Tang +4 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Applied Sciences, 2021 Validation of the EBD-SIM (evidence-based design-simulation) framework, a conceptual framework developed to integrate the use of lighting simulation in the EBD process, suggested that EBD’s post-occupancy evaluation (POE) should be conducted more ...
Anahita Davoodi +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Design of farm winery façades for the optimisation of indoor natural lighting: a case study
Journal of Agricultural Engineering, 2013 This paper deals with the theme of daylighting performances of rural buildings, within a broader research context aimed at establishing design criteria for farm wineries. The objective is to benchmark the performances of different window systems in order
Daniele Torreggiani +3 more
doaj +1 more source
A Method to Introduce Building Performance Simulation to Beginners
Energies, 2020 Competence in performing Building Performance Simulations (BPS) is a fundamental asset for an energy specialist. However, teaching BPS to new students can be challenging, often due to the overwhelming capabilities of the software.
Niko Gentile +2 more
doaj +1 more source