Results 41 to 50 of about 13,297,292 (248)

A Method to Introduce Building Performance Simulation to Beginners

Energies, 2020
Competence in performing Building Performance Simulations (BPS) is a fundamental asset for an energy specialist. However, teaching BPS to new students can be challenging, often due to the overwhelming capabilities of the software.
Niko Gentile, Jouri Kanters, Henrik Davidsson   +2 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The Study of Architectural Geometry and Shape in the Energy Balance of Glazed Roofs

Buildings, 2022
Triggered by the global call for low-carbon design, the idea of “productivity for a building envelope” has permeated the role of building to produce alternative (renewable) energy alongside weather and solar protection, and the authors hypothesized that ...
Yijia Miao, Ping Liu, Ivan Chin Shing Fu, Qinghua Lei, Stephen Siu Yu Lau, Yiqi Tao   +5 more
doaj   +1 more source

External coupling between BES and HAM programs for whole building simulation [PDF]

, 2009
This paper discusses a procedure for the two-way runtime external coupling between Building EnergySimulation (BES) and building envelope Heat, Air and Moisture (HAM) programs for enhanced wholebuilding simulation.
Blocken, B.J.E., Kelly, N.J., Hensen, J.L.M., Costola, D., Strachan, P.A., Kummert, M.   +5 more
core   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

First experiences using climate scenarios for The Netherlands in building performance simulation [PDF]

, 2009
In the beginning of 2008 the new Dutch standard NEN 5060:2008 (NEN,2008) was published (status is still ‘preliminary’). The standard contains four new weather data files for various applications.
Struck, C., Evers, J.E.J., Struck, C Christian, Hensen, J.L.M., Plokker, W., Wijsman, AJTM, Wijsman, A.J.T.M., Plokker, W, Evers, JEJ Janneke, Hensen, JLM Jan   +9 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Building performance simulation for sensemaking in architectural pedagogy

Buildings & Cities
During sensemaking one constructs meaning from one’s chaotic surrounding information; cues are extracted and attended to such that action is possible. Within architecture, making sense of quantitative information (e.g.
Martha Bohm
doaj   +1 more source

PEDRERA. Positive Energy District Renovation Model for Large Scale Actions

Energies, 2021
In this paper, we provide a view of the ongoing PEDRERA project, whose main scope is to design a district simulation model able to set and analyze a reliable prediction of potential business scenarios on large scale retrofitting actions, and to evaluate ...
Paolo Civiero, Jordi Pascual, Joaquim Arcas Abella, Ander Bilbao Figuero, Jaume Salom   +4 more
doaj   +1 more source