Results 41 to 50 of about 102,563 (261)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The Study of Architectural Geometry and Shape in the Energy Balance of Glazed Roofs

Buildings, 2022
Triggered by the global call for low-carbon design, the idea of “productivity for a building envelope” has permeated the role of building to produce alternative (renewable) energy alongside weather and solar protection, and the authors hypothesized that ...
Yijia Miao, Ping Liu, Ivan Chin Shing Fu, Qinghua Lei, Stephen Siu Yu Lau, Yiqi Tao   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Building performance simulation for sensemaking in architectural pedagogy

Buildings & Cities
During sensemaking one constructs meaning from one’s chaotic surrounding information; cues are extracted and attended to such that action is possible. Within architecture, making sense of quantitative information (e.g.
Martha Bohm
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Effects of different architectural solutions on the thermal behaviour in an unconditioned rural building. The case of an Italian winery

Journal of Agricultural Engineering, 2018
Referring to the wine sector, in the Mediterranean area, most of the wine farms make use of unconditioned above-ground buildings constructed without a specific attention to temperature control, where indoor temperatures easily show trends in disagreement
Daniele Torreggiani, Alberto Barbaresi, Francesca Dallacasa, Patrizia Tassinari   +3 more
doaj   +1 more source

PEDRERA. Positive Energy District Renovation Model for Large Scale Actions

Energies, 2021
In this paper, we provide a view of the ongoing PEDRERA project, whose main scope is to design a district simulation model able to set and analyze a reliable prediction of potential business scenarios on large scale retrofitting actions, and to evaluate ...
Paolo Civiero, Jordi Pascual, Joaquim Arcas Abella, Ander Bilbao Figuero, Jaume Salom   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Analysis and Simulation on Energy Performance Based Design

Megaron, 2011
The definition of sustainability varies depending on the sector to which it is related. In the building sector, sustainability mainly covers “high performance building” requirements.
Gülsu ULUKAVAK HARPUTLUGİL
doaj