Results 41 to 50 of about 170,232 (267)
Energies, 2023 Lowering the temperatures in heating systems is the key to decarbonizing the heat supply in the building sector, because it is a door opener to greater integration of renewable heat, the use of excess heat and to improve compatibility for heat pumps ...
David Sauerwein +2 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
ANALYSIS OF ENERGY-EFFICIENT HOUSE LAYOUT DESIGN IN TROPICAL CLIMATE
Dimensi: Journal of Architecture and Built Environment, 2021 Energy-efficient residential provision is an essential concern for the present and future city development. Currently, the residential buildings contribute approximately 37.5% to significant energy consumption and carbon emissions, which mainly used for ...
Aisyah Zakiah
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Bibliographic Review of Data-Driven Methods for Building Energy Optimisation
BuildingsThis study presents a systematic bibliographic review of the application of Big Data and machine learning (ML) methods to improve energy efficiency in architectural design.
Carlos Rizo-Maestre +3 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Understanding shading through home-use experience, measurement and modelling
Buildings & CitiesInsufficient application of the socio-technical influences on residential energy ‘optimisation’ exacerbates the energy performance gap. This is evident in the modelling of energy and thermal performance.
Magdalena Baborska-Narożny +2 more
doaj +1 more source
An Iterative Methodology for Model Complexity Reduction in Residential Building Simulation
Energies, 2019 The present paper introduces an iterative methodology to progressively reduce building simulation model complexity with the aim of identifying potential trade-offs between computational requirements (i.e., model complexity) and energy estimation accuracy.
Mattia De Rosa +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source