Results 41 to 50 of about 5,879,005 (254)

Combined Effects of Exterior Shading and A/C Heat Rejection on Building Energy Consumption and Indoor Air Pollution Exposure

Buildings, 2023
Exterior shading devices and outdoor units can be closely coupled since these two building components are commonly installed next to each other. This study uses a coupled EnergyPlus-Fluent modeling approach to examine how a combination of exterior ...
Xuyang Zhong, Zhiang Zhang, Ruijun Zhang, Zijian Wu   +3 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Implementation and demonstration of a building simulation based testbed for assessment of data centre multi-domain control strategies

, 2017
Publisher Copyright: © 2017 Building Simulation Conference Proceedings. All rights reserved.The traditional data centre (DC) infrastructure is being significantly extended by modern information technology (IT) trends on one side, and lasting calling for ...
Zavřel, Vojtěch, Torrens, J. Ignacio, Hensen, Jan L.M.   +2 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

BIM - Geometry modelling guidelines for building energy performance simulation [PDF]

, 2019
BS2013: 13th Conference of International Building Performance Simulation Association, Chambéry, France, 26-28 August 2013Building Information Models (BIM) are increasingly used as a central data repository from which designers transfer data from 3D CAD ...
Bazjanac, Vladimir, Rose, Cody, O'Donnell, James, Maile, Tobias   +3 more
core   +1 more source

An Advanced Fractional Order Method for Temperature Control

Fractal and Fractional, 2023
Temperature control in buildings has been a highly studied area of research and interest since it affects the comfort of occupants. Commonly, temperature systems like centralized air conditioning or heating systems work with a fixed set point locally set
Ricardo Cajo, Shiquan Zhao, Isabela Birs, Víctor Espinoza, Edson Fernández, Douglas Plaza, Gabriela Salcan-Reyes   +6 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Experimental and Numerical Analysis of Temperature Reduction Potentials in the Heating Supply of an Unrenovated University Building

Energies, 2023
Lowering the temperatures in heating systems is the key to decarbonizing the heat supply in the building sector, because it is a door opener to greater integration of renewable heat, the use of excess heat and to improve compatibility for heat pumps ...
David Sauerwein, Niall Fitzgerald, Christoph Kuhn   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source