Results 41 to 50 of about 169,526 (268)
Energies, 2023 Lowering the temperatures in heating systems is the key to decarbonizing the heat supply in the building sector, because it is a door opener to greater integration of renewable heat, the use of excess heat and to improve compatibility for heat pumps ...
David Sauerwein +2 more
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
ANALYSIS OF ENERGY-EFFICIENT HOUSE LAYOUT DESIGN IN TROPICAL CLIMATE
Dimensi: Journal of Architecture and Built Environment, 2021 Energy-efficient residential provision is an essential concern for the present and future city development. Currently, the residential buildings contribute approximately 37.5% to significant energy consumption and carbon emissions, which mainly used for ...
Aisyah Zakiah
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Understanding shading through home-use experience, measurement and modelling
Buildings & CitiesInsufficient application of the socio-technical influences on residential energy ‘optimisation’ exacerbates the energy performance gap. This is evident in the modelling of energy and thermal performance.
Magdalena Baborska-Narożny +2 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Bibliographic Review of Data-Driven Methods for Building Energy Optimisation
BuildingsThis study presents a systematic bibliographic review of the application of Big Data and machine learning (ML) methods to improve energy efficiency in architectural design.
Carlos Rizo-Maestre +3 more
doaj +1 more source
An Iterative Methodology for Model Complexity Reduction in Residential Building Simulation
Energies, 2019 The present paper introduces an iterative methodology to progressively reduce building simulation model complexity with the aim of identifying potential trade-offs between computational requirements (i.e., model complexity) and energy estimation accuracy.
Mattia De Rosa +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source