Results 51 to 60 of about 5,879,005 (254)

ANALYSIS OF ENERGY-EFFICIENT HOUSE LAYOUT DESIGN IN TROPICAL CLIMATE

Dimensi: Journal of Architecture and Built Environment, 2021
Energy-efficient residential provision is an essential concern for the present and future city development. Currently, the residential buildings contribute approximately 37.5% to significant energy consumption and carbon emissions, which mainly used for ...
Aisyah Zakiah
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Bibliographic Review of Data-Driven Methods for Building Energy Optimisation

Buildings
This study presents a systematic bibliographic review of the application of Big Data and machine learning (ML) methods to improve energy efficiency in architectural design.
Carlos Rizo-Maestre, Mireia Sempere-Tortosa, Pascual Saura-Hernández, María Dolores Andújar-Montoya   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Understanding shading through home-use experience, measurement and modelling

Buildings & Cities
Insufficient application of the socio-technical influences on residential energy ‘optimisation’ exacerbates the energy performance gap. This is evident in the modelling of energy and thermal performance.
Magdalena Baborska-Narożny, Karol Bandurski, Magdalena Grudzińska   +2 more
doaj   +1 more source

An Iterative Methodology for Model Complexity Reduction in Residential Building Simulation

Energies, 2019
The present paper introduces an iterative methodology to progressively reduce building simulation model complexity with the aim of identifying potential trade-offs between computational requirements (i.e., model complexity) and energy estimation accuracy.
Mattia De Rosa, Marcus Brennenstuhl, Carlos Andrade Cabrera, Ursula Eicker, Donal P. Finn   +4 more
doaj   +1 more source

Further developments in the conflation of CFD and building simulation [PDF]

, 2001
To provide practitioners with the means to tackle problems related to poor indoor environments, building simulation and computational fluid dynamics can usefully be integrated within a single computational framework.
Stankov, P., Denev, J., Beausoleil-Morrison, I., MacDonald, I.A., Macdonald, I., Melikov, A., Clarke, J.A., Macdonald, I. A.   +7 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source