Results 51 to 60 of about 1,174,972 (306)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The development of a generic systems-level model for combustion-based domestic cogeneration [PDF]

open access: yes, 2008
The provision of heat and power to dwellings from micro-cogeneration systems is gaining credence around the developed world as a possible means to reduce the significant carbon emissions associated with the domestic sector. However, achieving the optimum
Ferguson, Alex   +3 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Improving energy modeling of large building stock through the development of archetype buildings [PDF]

open access: yes, 2011
12th Conference of International Building Performance Simulation ...
Ballarini, Ilaria   +3 more
core  

Representing simmodel in the web ontology language [PDF]

open access: yes, 2014
Many building energy performance (BEP) simulation tools, such as EnergyPlus and DOE-2, use custom schema definitions (IDD and BDL respectively) as opposed to standardised schema definitions (defined in XSD, EXPRESS, and so forth).
Corry, Edward   +2 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

ANALYSIS OF ENERGY-EFFICIENT HOUSE LAYOUT DESIGN IN TROPICAL CLIMATE

open access: yesDimensi: Journal of Architecture and Built Environment, 2021
Energy-efficient residential provision is an essential concern for the present and future city development. Currently, the residential buildings contribute approximately 37.5% to significant energy consumption and carbon emissions, which mainly used for ...
Aisyah Zakiah
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Understanding shading through home-use experience, measurement and modelling

open access: yesBuildings & Cities
Insufficient application of the socio-technical influences on residential energy ‘optimisation’ exacerbates the energy performance gap. This is evident in the modelling of energy and thermal performance.
Magdalena Baborska-Narożny   +2 more
doaj   +1 more source

A co-operating solver approach to building simulation [PDF]

open access: yes, 2004
This paper describes the co-operating solver approach to building simulation as encapsulated within the ESP-r system.
Clarke, J. A., Tang, D.
core  

Home - About - Disclaimer - Privacy