Results 41 to 50 of about 811,371 (313)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Socio-Economic Determinants of Students’ Academic Achievement in Building Technology in North-Central Nigeria

Jurnal Pendidikan Teknologi dan Kejuruan, 2019
This study investigated socio-economic determinants of students’ academic achievement in building technology in North-central Nigeria. It was a quest to probe into the incessant cases of students’ poor achievement in building technology to identify ...
Yahaya Ibn Salihu, Nordin Safarin Mohd
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Advances in Cold-Climate-Responsive Building Envelope Design: A Comprehensive Review

Buildings
Extreme low temperatures, heavy snowfall, ice accumulation, limited daylight, and increased energy consumption in cold climates present significant challenges but also offer opportunities for improving building efficiency.
Zahra Al-Shatnawi, Caroline Hachem-Vermette, Michael Lacasse, Bahador Ziaeemehr   +3 more
doaj   +1 more source

Effect of α: Phase Nano Al2O3 and Rice Husk Ash in Cement Mortar

Advances in Civil Engineering, 2022
The study focused on the investigation of the influence of α-phase nano Al2O3 (NA) and M-sand as a fine aggregate on the partial replacement of cement by micro rice husk ash (MRHA) to enhance the mechanical properties and durability of mortar and achieve
Alexander Gladwin Alex, Zeyneb Kemal, Tsegay Gebrehiwet, Solomon Getahun   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Climate responsive and safe earthquake construction: a community building a school

Journal of Natural Resources and Development, 2011
This article outlines environment friendly features, climate responsive features and construction features of a prototype school building constructed using green building technology.
Hari Darshan, Jishnu Subedi, Ryuichi Yatabe, Netra Prakash Bhandary   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source