Results 91 to 100 of about 2,125,522 (310)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Human Rights, Indigenous Peoples, and the Pursuit of Justice [PDF]

open access: yes, 2016
There are three major problems with the use of the rights-based approach to tackle issues of Indigenous justice: It privileges (the worldview of) the dominant legal culture; It artificially restricts the conversation about causes of and ...
Hendry, J, Tatum, ML
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Getting to Common Ground: A Comparison of Ontario, Canada’s Provincial Policy Statement and the Auckland Council Regional Policy Statement with Respect to Indigenous Peoples

open access: yesUrban Planning, 2017
Indigenous rights are crucial to contemporary land use planning and policy in settler states. This article comparatively analyzes the manifest and latent content of the 2014 Provincial Policy Statement of Ontario, Canada (PPS) and the 1999 Auckland ...
Fraser McLeod   +3 more
doaj   +1 more source

Legal implications of not extending building use rights on state-owned land

open access: yesInternational journal of humanities, literature and arts
This study discusses the legal implications arising from the failure to extend the Right to Build (HGB) on state-owned land using a literature review method. The failure to extend the HGB results in the land reverting to state ownership and severing the legal relationship between the HGB holder and the land.
Salmon Sihite, Gunawan Widjaja
openaire   +1 more source

Community based game ranching and politics in Chiriwo ward of Mbire district, Zimbabwe [PDF]

open access: yes, 2010
Community based wildlife management in Zimbabwe is rooted in ideas of global significance whose central premise is that local communities will manage natural resources sustainably when rights and responsibilities are devolved to them; benefits of ...
Le Bel, Sébastien, Mombeshora, Solomon
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Free to Trust? Economic Freedom and Social Capital [PDF]

open access: yes
We present new evidence on how generalized trust is formed. Unlike previous studies, we look at the explanatory power of economic institutions, we use newer data, we incorporate more countries, and we use instrumental variables to handle the causality ...
Berggren, Niclas, Jordahl, Henrik
core  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy