Results 61 to 70 of about 2,125,522 (310)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Sports Sponsorship As A Tool For Customer Engagement [PDF]

, 2010
This paper reports the findings from a series of semi-structured interviews with Sponsorship Managers in major UK-based sports sponsors. The key theme explored is the use of sponsorship leverage strategies as a means of deepening engagement with both ...
Donlan, Leah
core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Current policy issues in the governance of the European patent system [PDF]

, 2009
The European Parliament has been working towards building a discussion platform and a resource for further policy actions in the field of intellectual property rights.
Granstrand, Ove, Leijten, Jos, Poti, Bianca, Rodriguez, Victor, Scellato, Giuseppe   +4 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

USING THE COMBINED LADM-INDOORGML MODEL TO SUPPORT BUIILDING EVACUATION [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2018
During an incident, many people that are located in indoor environments require to follow emergency evacuation procedures. The ‘emergency evacuation’ term has been defined as ‘a critical movement of people from a dangerous area due to the risk or an ...
A. Alattas, A. Alattas, P. van Oosterom, S. Zlatanova, D. Hoeneveld, E. Verbree   +5 more
doaj   +1 more source

Refusal of Extension of Building Use Rights Over Management Rights on Land (Study of Supreme Court Decision Number 1343/K/Pdt/2021)

International Journal of Multicultural and Multireligious Understanding, 2023
Building use rights (HGB) with certificate No. 172 and HGB No. 213 Pisang Selatan is located at Jln. Sungai Saddang, Ruko Latanete Plaza Blok C.No. 1 & 2 Makassar, granted over the Right to Management of the Regional Government of South Sulawesi Province in the name of Herman Suryanto, which was legally obtained in 2008, with the expiration of the ...
Kamaluddamairi Usman, Suhaimi Suhaimi, Muhammad Ya’kub Aiyub Kadir   +2 more
openaire   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Legal Regulations and Implications of Building Use Rights on Land Management Rights for Public Assets

Journal of Law, Politic and Humanities
This article is entitled the regulation and legal implications of building use rights over land management rights for public assets. Using legal research methods with normative research types, using statute research approaches and conceptual approaches .
Jessica Calista, Benny Djaja
openaire   +1 more source