Results 101 to 110 of about 161,475 (253)
Advanced Science, EarlyView.Grounded in real biological RNA‐seq data, the framework benchmarks ten differential transcript usage (DTU) methods across short‐read bulk, long‐read bulk, long‐read single‐cell, and long‐read spatial transcriptomics. By integrating reference transcript sets with ranked DTU results, the Transcript Set Enrichment Score (TSES) identifies data‐type ...
Chenxing Zhang +6 more
wiley +1 more source
Contemporary AgricultureOnion (Allium cepa L.) is the most widely cultivated species of the genus Allium and one of the most consumed vegetables globally. With the aim of supporting onion cultivation practices and breeding programs, this study examined the main classes of ...
Kilibarda Sofija +4 more
doaj +1 more source
Brain Network Dynamics of Local and Global Predictive Processing in Aging
Advanced Science, EarlyView.Separation of concurrent whole‐brain networks in source‐reconstructed magnetoencephalography (MEG) data suggests that healthy aging reorganizes, rather than uniformly attenuates, neural responses elicited from hierarchical auditory violations. Enhanced early sensory deviance processing alongside reduced higher‐order cognitive responses suggests a large‐
Mathias Houe Andersen +9 more
wiley +1 more source
Advanced Science, EarlyView.Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han +11 more
wiley +1 more source
Advanced Science, EarlyView.Three phenothiazine‐based polyamides featuring gradually strengthened electron‐withdrawing linkers are developed as high‐voltage cathodes for lithium‐organic batteries. The linker motif serves not only as a structural bridge to suppress solubility, but also as a functional design element that governs optoelectronic properties and electron/ion transport
Shujuan Cao +4 more
wiley +1 more source
Advanced Science, EarlyView.AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang +19 more
wiley +1 more source
Advanced Science, EarlyView.Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li +9 more
wiley +1 more source
Advanced Science, EarlyView.Parkinson's disease currently has no disease‐modifying therapies. In Caenorhabditis elegans, Escherichia coli E8 alleviates α‐synuclein‐provoked PD‐related defects through its bioactive metabolite 1‐ALPP, which combats PD by triggering AMPK/mTOR/HLH‐30‐dependent autophagy and suppressing α‐synuclein LLPS‐mediated fibrillization.
Mingqin Qu +12 more
wiley +1 more source
Flexible Integration of Structurally Diverse Spatial Multi‐Omics With AgaeSMO
Advanced Science, EarlyView.AgaeSMO is a versatile and robust deep learning framework for flexible cross‐integration of spatial multi‐omics data. Leveraging a GATs network with a graph attention module, it learns joint embedding across diverse modalities, enabling integration of both structurally paired (e.g., spatial transcriptome‐epigenome, transcriptome‐proteome, transcriptome‐
Kunpeng Liu +9 more
wiley +1 more source