Results 71 to 80 of about 775,507 (192)

Neurodegenerative Diseases: Epidemiology, Risk Factors, Classification, Pathophysiology, Clinical Features, Diagnosis, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neurodegenerative diseases share convergent risk architectures and pathological mechanisms, yet diverge in selective vulnerability, clinical presentation, and therapeutic responsiveness. This review integrates cross‐disease epidemiology, pathophysiology, diagnosis, and treatment, highlighting the transition from symptomatic care toward biomarker‐guided
Zimeng He, Jingjing Zeng, Guoqing Wang, Yuxin Li, Feng Zhang   +4 more
wiley   +1 more source

Progressive Supranuclear Palsy

, 2020
Progressive Supranuclear Palsy (PSP) is a rare progressive neurodegenerative disorder that affects certain parts of the brain, resulting in difficulty with balance, walking, swallowing, and ...
NANOS
core  

Phase 3 randomized trial of latozinemab in frontotemporal dementia due to GRN mutations

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Heterozygous progranulin gene mutations causing frontotemporal dementia (FTD‐GRN) are associated with deficiency in progranulin (PGRN). Latozinemab is a human monoclonal immunoglobulin G1 (IgG1) antibody designed to elevate PGRN levels in people with heterozygous loss‐of‐function (LOF) GRN mutations.
Adam Simmons, Bradley Boeve, Isabelle Le Ber, Barbara Borroni, Catherine Mummery, Jonathan D. Rohrer, Giovanna Zamboni, Oezguer A. Onur, James B. Rowe, Adam L. Boxer, Tina Schwabe, Olga I. Kahn, Julie Y. Huang, Hua Long, Ruchi Gupta, Jinglin Zhong, Caiyan Li, Leonard Guizzetti, Lawrence P. Carter, Tuan Nguyen, Tiffany W. Chow, Balasubrahmanyam Budda, Lovingly Park, Sam Jackson, Robert Paul, Michael Ward, Gary Romano, Sara Kenkare‐Mitra, Arnon Rosenthal, Giacomo Salvadore, Arthur J. Mayorga   +30 more
wiley   +1 more source

Progressive supranuclear palsy: progression and survival.

, 2016
Progressive supranuclear palsy (PSP) is a progressive neurodegenerative disorder characterized by postural instability and falls, vertical supranuclear gaze palsy, parkinsonism with poor levodopa response, pseudobulbar palsy, and frontal release signs ...
Arena, Julieta E;Weigand, Stephen D;Whitwell, Jennifer L;Hassan, Anhar;Eggers, Scott D;Höglinger, Günter U;Litvan, Irene;Josephs, Keith A
core   +1 more source

Human biomarker navigator

iMeta, Volume 5, Issue 5, October 2026.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Late Presenting Central Pontine Myelinolysis Post- tonsillectomy in a Child: Case Report [PDF]

Pediatric Sciences Journal (Egypt)
Central pontine myelinolysis (CPM) is a notorious grave complication of rapid correction of hyponatremia. CPM is a noninflammatory demyelination. It presents clinically with variable degrees of loss of coordination, unconsciousness, blurred vision ...
Magd Ahmed Kotb, Menat-allah Mahmoud Elzabet, Walaa Elnaggar   +2 more
doaj   +1 more source

Myelination and Remyelination in Peripheral Nerve Injury: Mechanisms, Regulation, and Therapeutic Perspectives

MedComm, Volume 7, Issue 10, October 2026.
Peripheral nerve injury triggers axonal degeneration, myelin breakdown, and Schwann cell reprogramming. Remyelination requires reactivation of the SOX10–OCT6–KROX20/EGR2 transcriptional hierarchy, axonal NRG1–ErbB2/3 signaling, metabolic support, and coordinated immune regulation.
Li‐Xin Huang, Tao Sun, Yi‐Bo Zhao, Zhi‐Min Wu, Jun Sun, Ming‐Yang Li, Qing‐Yi Huo, Yun‐Mou Ou, Qing‐Tian Liang, Cong Ling, Bao‐Yu Zhang, Chuan Chen, Ying Guo, Hui Wang   +13 more
wiley   +1 more source

Precision Medicine in Neurodegeneration with Brain Iron Accumulation (NBIA) Disorders: An Update on Emerging Treatments

Movement Disorders Clinical Practice, Volume 13, Issue 10, Page 2405-2418, October 2026.
Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider, Divyani Garg, Vassilena Iankova, Thomas Klopstock   +3 more
wiley   +1 more source

Brown-Vialetto-Van Laere Syndrome, a Ponto-Bulbar Palsy with Deafness, Is Caused by Mutations in C20orf54

, 2010
Brown-Vialetto-Van Laere syndrome is a rare neurological disorder with a variable age at onset and clinical course. The key features are progressive ponto-bulbar palsy and bilateral sensorineural deafness.
Crow, Yanick J., Sheridan, Eamonn, Josifova, Dragana, Josifova, Dragana J., Green, Peter, Lin, Jean-Pierre, Houlden, Henry, Lin, Jean Pierre, Childs, Anne Marie, Riphagen, Shelley, Childs, Anne-Marie, Raymond, F. Lucy, Wiseman, Matthew, Edwards, Sian   +13 more
core   +1 more source

SPG4 Hereditary Spastic Paraplegia: From Etiology to Therapy

Movement Disorders, Volume 41, Issue 10, Page 2592-2605, October 2026.
Abstract Hereditary spastic paraplegias (HSPs) comprise a heterogeneous group of heritable neurodegenerative disorders resulting from mutations in a wide variety of genes. HSP locomotor symptoms include lower limb weakness and spasticity that arise from progressive degeneration of corticospinal axons projecting from the motor cortex to the distal ...
Emanuela Piermarini, Peter W. Baas
wiley   +1 more source