Results 141 to 150 of about 20,177 (294)

Switching disease‐modifying therapies in patients with spinal muscular atrophy: A systematic review on effectiveness outcomes

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
With multiple disease‐modifying therapies now available, treatment switching has become an important clinical consideration in the management of spinal muscular atrophy (SMA). While some switches are prompted by suboptimal clinical response, more commonly they are driven by treatment burden, convenience, or adverse events.
Andrej Belančić   +4 more
wiley   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

open access: yesBMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie   +12 more
wiley   +1 more source

A Diagnostic Crossroads: Bulbar Weakness Mimicking ALS in a Seropositive Myasthenia Gravis Patient— A Case Report

open access: yes
Abstract Bulbar-onset Amyotrophic Lateral Sclerosis (ALS) and Myasthenia Gravis (MG) may present with overlapping clinical features, complicating early diagnosis. We report the case of a 30-year-old woman with progressive dysarthria, dysphagia, and tongue fasciculations initially suggestive of bulbar-onset ALS.
Beruk Ketema, Feryat Leul
openaire   +1 more source

The Use of Renewable Energy in Prominent City Buildings: A Diffusion Study on Top European Football Organizations

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT The present study applied the diffusion of innovation theory to investigate the rate of diffusion of renewable energy sources used by Europe's top professional football stadiums and the relationship with carbon neutrality. A discrete diffusion model estimated the diffusion of renewable energy to saturation, and a multivariate logistic ...
Chad S. Seifried   +2 more
wiley   +1 more source

GUILLAIN-BARRÉ SYNDROME ASSOCIATED WITH ACUTE HEV HEPATITIS

open access: yesIMC Journal of Medical Science, 2008
Guillain-Barré Syndrome (GBS) otherwise known as Acute Inflammatory Polyneuritis, characterized by acute progressive limb weakness and aretlexia, is the prototype of a post infectious autoimmune disease.
Rawshan Ara Khanam   +3 more
doaj  

Chiari I Malformation: Review and Update of Current Treatment Options

open access: yesClinical Anatomy, EarlyView.
ABSTRACT The pathophysiology of Chiari malformation type I (CM‐I) is complex, involving structural abnormalities at the craniovertebral junction that result in herniation of the cerebellar tonsils through the foramen magnum. In this study, we aim to present and evaluate current treatment options for CM‐I, with a focus on evidence‐based clinical ...
Jordan J. Lo   +11 more
wiley   +1 more source

Simultaneous Construction of Hydrophobic Environment and Optimized Ion Channels in V2O5 for Zinc Ion Batteries

open access: yesCarbon Energy, EarlyView.
With the preinsertion of hexamethylenebisammonium (HMA2+), the thermodynamic stability of V2O5 is improved, and the kinetics of electrochemical reaction are enhanced, benefiting from the pillar effect, hydrophobicity, and electrostatic shielding of HMA2+.
Leilei Sun   +11 more
wiley   +1 more source

Early Dropped Head Syndrome In A Case With Amyotrophic Lateral Sclerosis

open access: yesAnnals of Indian Academy of Neurology, 2005
We Report a case of "Dropped head syndrome" [DHS] due to Amyotrophic lateral sclerosis [ALS]. A thirty seven year old gentleman was admitted with progressive limb and bulbar weakness of 10 months duration.
Shanbhogue K R   +6 more
doaj  

Ultrafast Sodium‐Ion Storage in Self‐Doped 2D PVP‐VS4/Ti3C2Tx Hybrids for High‐Performance Sodium‐Ion Half/Full Batteries

open access: yesCarbon Energy, EarlyView.
Self‐doped PVP‐VS4/Ti3C2Tx with sulfur vacancies enhances the structural stability and exhibits excellent electrochemical performance. ABSTRACT Transition metal sulfides demonstrate remarkable theoretical specific capacities, making them highly desirable anode materials for sodium‐ion batteries (SIBs).
Mingxuan Tang   +5 more
wiley   +1 more source

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