Results 41 to 50 of about 20,177 (294)

Beta-agonist stimulation ameliorates the phenotype of spinal and bulbar muscular atrophy mice and patient-derived myotubes [PDF]

, 2017
Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease characterized by the loss of lower motor neurons. SBMA is caused by expansions of a polyglutamine tract in the gene coding for androgen receptor (AR).
Blaauw, Bert, Borgia, Doriana, Gomes Pereira, Marcelo, Lieberman, Andrew P., Maino, Eleonora, Malena, Adriana, Marchioretti, Caterina, Milioto, Carmelo, Pegoraro, Elena, Pennuto, Maria, Pennuto, Maria, Plebani, Mario, Polanco, Maria J., Sambataro, Fabio, Sambataro, Fabio, Sorar, Gianni, Soraru', Gianni, Venturini, Roberta, Vergani, Lodovica   +18 more
core   +3 more sources

Clinical Features of Myasthenia Gravis With Antibodies to MuSK Based on Age at Onset: A Multicenter Retrospective Study in China

Frontiers in Neurology, 2022
IntroductionAntibodies to MuSK identify a rare subtype of myasthenia gravis (MuSK-MG). In western countries, the onset age of MuSK-MG peaks in the late 30's while it is unknown in Chinese population.MethodsIn this retrospective multicenter study, we ...
Yufan Zhou, Yufan Zhou, Yufan Zhou, Jialin Chen, Zunbo Li, Song Tan, Song Tan, Chong Yan, Chong Yan, Chong Yan, Sushan Luo, Sushan Luo, Sushan Luo, Lei Zhou, Lei Zhou, Lei Zhou, Jie Song, Jie Song, Jie Song, Xiao Huan, Xiao Huan, Xiao Huan, Ying Wang, Chongbo Zhao, Chongbo Zhao, Chongbo Zhao, Wenshuang Zeng, Jianying Xi, Jianying Xi, Jianying Xi   +29 more
doaj   +1 more source

An Atypical Case of Myasthenia Gravis: Purely Bulbar in a Young Male

McGill Journal of Medicine, 2020
Myasthenia Gravis (MG), an uncommon autoimmune syndrome caused by the failure of neuromuscular transmission, results from bind- ing of autoantibodies to proteins that are involved in signaling at the neuromuscular junction (1).
Muhammad Amer Saleem, Faizan Pervaiz, Anum Yousaf, Muhammad Amer Saleem   +3 more
doaj  

Myasthenic Crisis in an Elderly Patient with Positive Antibodies against Acetylcholine and Anti-MuSK, Successfully Treated with Noninvasive Mechanical Ventilation

Case Reports in Critical Care, 2015
Myasthenia gravis is an autoimmune disease characterized by muscle weakness. Subjects with antibodies against acetylcholine usually have greater ocular symptoms, lower bulbar weakness, and fewer respiratory complications, compared to individuals with ...
José A. Fernández, Antonio Fernández-Valiñas, Daniel Hernández, Joel Orozco, Antonio Lugo   +4 more
doaj   +1 more source

A case of generalized myasthenia gravis with bilateral optic neuritis – A rare association

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2020
Myasthenia gravis (MG) is a relatively uncommon autoimmune disorder of neuromuscular junction characterized by fatigable muscle weakness, bulbar symptoms, and weakness of extraocular muscles with a significant diurnal variation.
Atanu Chandra, Anirban Ghosh, Uddalak Chakraborty, Indranil Sen   +3 more
doaj   +1 more source

Exploring Factors Influencing Complete Denture Management of Patient with Myasthenia Gravis

Balkan Journal of Dental Medicine, 2020
Background/Aim: The purpose of this literature review and case report was to highlight the oral symptoms and the pathophysiology of Myasthenia Gravis (MG). MG is an autoimmune, antibody-mediated neuromuscular disorder.
Kamalakidis Savvas, Papaemmanouil Georgios, Anastassiadou Vassiliki   +2 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Atypical bulbar myasthenia gravis in an elderly male unmasked by levofloxacin: a diagnostic challenge

European Journal of Case Reports in Internal Medicine
Background: Myasthenia gravis (MG) is an autoimmune neuromuscular disorder that typically presents with ocular symptoms. Isolated bulbar symptoms, such as dysphagia and dysarthria, are rare, and most commonly seen in men with late-onset MG. We report one
Mrudula Thiriveedi, Anil Chimakurthy, Siddharth Patel, Sujatha Baddam, Rafik ElBeblawy, Punuru J. Reddy   +5 more
doaj   +1 more source

Anti-MuSK-Positive Myasthenia Gravis in a Patient with Parkinsonism and Cognitive Impairment

Neurology Research International, 2011
Muscle-specific tyrosine kinase- (MuSK-) antibodies-positive Myasthenia Gravis accounts for about one third of Seronegative Myasthenia Gravis and is clinically characterized by early onset of prominent bulbar, neck, shoulder girdle, and respiratory ...
S. Lanfranconi, S. Corti, P. Baron, G. Conti, L. Borellini, N. Bresolin, A. Bersano   +6 more
doaj   +1 more source