Results 41 to 50 of about 5,242,910 (302)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin   +2 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Bulk water suppliers in the City of Harare – An endogenous form of privatisation of urban domestic water supply in Zimbabwe?

open access: yesWater Alternatives, 2016
This paper investigates the phenomenon of bulk water suppliers in the city of Harare, Zimbabwe’s largest urban metropolis and capital. Bulk water suppliers began in 2005 to sell domestic water to middle- and high-income suburbs because of shortcomings in
Emmanuel Manzungu,   +2 more
doaj  

Examining the link between the antecedents of relationship commitment and loyalty within the road transport industry of South Africa [PDF]

open access: yesThe Retail and Marketing Review, 2018
Purpose – The study investigates the extent to which the relationship commitment by customers of road transport service providers is influenced by trust, communication, shared values and the attractiveness of alternatives.
WL Jackson   +2 more
doaj  

An M[X]/G(a,b)/1 Queueing System with Breakdown and Repair, Stand-By Server, Multiple Vacation and Control Policy on Request for Re-Service

open access: yesMathematics, 2018
In this paper, we discuss a non-Markovian batch arrival general bulk service single-server queueing system with server breakdown and repair, a stand-by server, multiple vacation and re-service.
G. Ayyappan, S. Karpagam
doaj   +1 more source

On the Analysis of a M/M/1 Queue with Bulk Services [PDF]

open access: yesThe Computer Journal, 2013
The analysis of a queue that serves batches of customers with a novel service policy is presented in this paper, showing that a closed steady-state distribution of the number of customers in the queue can be derived for a very general setting of its parameters.
BALBO, Gianfranco   +1 more
openaire   +3 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Polymer–Fullerene Bulk Heterojunction Solar Cells [PDF]

open access: yes, 2005
Nanostructured phase-separated blends, or bulk heterojunctions, of conjugated polymers and fullerene derivatives form a very attractive approach to large-area, solid-state organic solar cells.
Sariciftci, N. Serdar,   +17 more
core   +2 more sources

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