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The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens+8 more
wiley +1 more source
In comparison with the single-bundle technique, double-bundle anterior cruciate ligament (ACL) reconstruction has proven its superiority regarding biomechanical studies and clinical outcomes in both rotational knee stability and anterior translation ...
Cong Dung Truong, M.D.+7 more
doaj
On the topology of holomorphic bundles [PDF]
In this work we study the topology of holomorphic rank two bundles over complex surfaces. We consider bundles that are constructed by glueing and show that under certain conditions the topology of the bundle does not depend on the glueing. We present a simple classification of bundles on blown-up surfaces.
arxiv
We show that a twistor construction of Hitchin and Ward can be adapted to study unitons (harmonic spheres in a unitary group). Specifically, we show that unitons are equivalent to holomorphic bundles with extra structure over a rational ruled surface with energy given by Chern class.
openaire +2 more sources
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink+6 more
wiley +1 more source
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi+3 more
wiley +1 more source
Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha+6 more
wiley +1 more source
A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini+11 more
wiley +1 more source
Adhering to a national surgical care bundle reduces the risk of surgical site infections.
BackgroundIn 2008, a bundle of care to prevent Surgical Site Infections (SSIs) was introduced in the Netherlands. The bundle consisted of four elements: antibiotic prophylaxis according to local guidelines, no hair removal, normothermia and 'hygiene ...
Mayke B G Koek+7 more
doaj +1 more source
A Fourier transform for Higgs bundles [PDF]
We define a Fourier-Mukai transform for Higgs bundles on smooth curves and study its properties. It is shown that the transform of a stable zero-degree Higgs bundle is an algebraic vector bundle on the cotangent bundle of the Jacobian of the curve. We show that this transformed bundle admits a natural extension to an algebraic vector bundle over a ...
arxiv