Results 101 to 110 of about 1,098,643 (378)
Journal of the London Mathematical Society, 1996 Just as $\Cstar$ principal bundles provide a geometric realisation of two-dimensional integral cohomology; gerbes or sheaves of groupoids, provide a geometric realisation of three dimensional integral cohomology through their Dixmier-Douady class. I consider an alternative, related, geometric realisation of three dimensional cohomology called a bundle ...
openaire +4 more sources
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Regression Model Decreasing the Risk of Femoral Neurovascular Bundle Accidental Puncture [PDF]
, 2022 Juan Antonio Valera‐Calero +4 more
openalex +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Journal of Infection and Public Health, 2020 Introduction: Ventilator-associated pneumonia (VAP) is a nosocomial infection that develops 48 h after the initiation of mechanical ventilatory support.
Sara Osman +5 more
doaj +1 more source
Use of a pathway quality improvement care bundle to reduce mortality after emergency laparotomy
British Journal of Surgery, 2014 Emergency laparotomies in the UK, USA and Denmark are known to have a high risk of death, with accompanying evidence of suboptimal care. The emergency laparotomy pathway quality improvement care (ELPQuiC) bundle is an evidence‐based care bundle for ...
S. Huddart +6 more
semanticscholar +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Geometry of Bounded Frechet Manifolds
, 2018 In this paper we develop the geometry of bounded Fr\'echet manifolds. We prove that a bounded Fr\'echet tangent bundle admits a vector bundle structure.
Eftekharinasab, Kaveh
core
Analysis of 3-dimensional interventricular septum and abnormal muscle bundles models for septal myectomy [PDF]
, 2021 Uladzimir Andrushchuk +5 more
openalex +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source