Results 151 to 160 of about 57,705 (306)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Highlighting the Importance of His Bundle Potential During Tachycardia and Ventricular Overdrive Pacing. [PDF]

J Arrhythm
Matsunaga-Lee Y, Egami Y, Yasumoto K, Yano M, Nishino M.   +4 more
europepmc   +1 more source

Experimental Evaluation of Some Controversial Points Regarding the A-V Conduction Disturbances in the Clinical His Bundle Electrogram

, 1975
Kazumasa Hiejima, Fumio Suzuki
openalex   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Permanent HIS bundle Pacing Feasibility in Routine Clinical Practice: Experience from an Indian Center

, 2019
Rakesh Sarkar, Daljeet Kaur, Muthiah Subramanian, Sachin Yalagudri, C. Sridevi, Soumen Devidutta, Debabrata Bera, Calambur Narasimhan   +7 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

An unwanted left bundle branch block: The proteus-unveiling of his bundle pacing

HeartRhythm Case Reports
Mirco Lazzeri, MD, Michele Bertelli, MD, Alessandro Carecci, MD, Andrea Angeletti, MD, Matteo Ziacchi, MD, Mauro Biffi, MD   +5 more
doaj   +1 more source

Is conduction system pacing improving cardiac performance in patients with right bundle branch block and heart failure? [PDF]

Front Physiol
Jing-Jing J, Xi-Xia S, Tian-Zhu L, Xin W, Xiao-Lei Y, Xin-Jing A, Yun-Long X, Ying-Xue D.   +7 more
europepmc   +1 more source

Direct endoscopic visualization of physiological His-bundle pacing and surrounding anatomy within reanimated human hearts using visible heart methodologies [PDF]

, 2019
Alexander R. Mattson, Zhongping Yang, Paul A. Iaizzo   +2 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source