Results 221 to 230 of about 167,623,224 (301)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Mobitz Type I Progressing to High-Grade AV Block: Beyond Wenckebach. [PDF]

JACC Case Rep
Trube J, Khanani A, Sze CH, Haber T, Williams J.   +4 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Left bundle branch pacing in double-chambered left ventricle and perimembranous ventricular septal aneurysm: a case report. [PDF]

Eur Heart J Case Rep
Brečko K, Zupan Mežnar A, Pavšič N, Bervar M, Žižek D.   +4 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Transitioning into the new era of conduction system pacing (CSP): a district general hospital experience. [PDF]

Br J Cardiol
Salisbury T, Appalanaidu N, Coe C, Kuhar H, Haynes Z, Nelson T, Sheridan P, Lee D.   +7 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Cardiac implantable electronic devices in heart failure: needs, challenges, and real-world implementation. [PDF]

Heart Fail Rev
Žižek D, Mrak M, Mežnar AZ, Ivanovski M, Žlahtič T, Barrientos CF, Ambrosy AP, Fras Z, Biffi M, Lainscak M.   +9 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Left bundle branch area pacing: anatomical and physiological features made easy. [PDF]

Eur Heart J Open
Imnadze G, Abdin A, Biffi M, Cabrera JÁ, Cano Ó, De Pooter J, Didenko M, Jastrzebski M, Mullens W, Vernooy K, Vijayaraman P, Burri H.   +11 more
europepmc   +1 more source