Mutations in the Schmallenberg virus Gc glycoprotein facilitate cellular protein synthesis shutoff and restore pathogenicity of NSs deletion mutants in mice [PDF]
, 2016 Serial passage of viruses in cell culture has been traditionally used to attenuate virulence and identify determinants of viral pathogenesis. In a previous study, we found that a strain of Schmallenberg virus (SBV) serially passaged in tissue culture ...
Aislynn Taggart +13 more
core +1 more source
Uirusu, 2012 The family Bunyaviridae consists of over 300 virus species and strains that are divided into 5 genera: orthobunyavirus, hantavirus, nairovirus, phlebovirus, and tospovirus. All members of family Bunyaviridae possess a negative-sense, single stranded tripartite RNA genome, consisting of large (L), medium (M) and small (S) segments, which encode an RNA ...
Kumiko, Yoshimatsu, Jiro, Arikawa
openaire +3 more sources
No Evidence of Gouléako and Herbert Virus Infections in Pigs, Côte d’Ivoire and Ghana
Emerging Infectious Diseases, 2015 A recent report suggested that 2 novel bunyaviruses discovered in insects in Côte d’Ivoire caused lethal disease in swine in South Korea. We conducted cell culture studies and tested serum from pigs exposed to mosquitoes in Côte d’Ivoire and Ghana and ...
Sandra Junglen +11 more
doaj +1 more source
Functional analysis of the Bunyamwera orthobunyavirus Gc glycoprotein [PDF]
, 2009 The virion glycoproteins Gn and Gc of Bunyamwera orthobunyavirus (family Bunyaviridae) are encoded by the M RNA genome segment and have roles in both viral attachment and membrane fusion.
Brauburger, K. +4 more
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Culex tarsalis is a competent vector species for Cache Valley virus [PDF]
, 2018 Background: Cache Valley virus (CVV) is a mosquito-borne orthobunyavirus endemic in North America. The virus is an important agricultural pathogen leading to abortion and embryonic lethality in ruminant species, especially sheep.
Alto, Barry W. +10 more
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Recent Progress in Bunyavirus Research [PDF]
, 2017 The Bunyaviridae is the largest family of RNA viruses, with over 350 isolates worldwide distributed into five genera (i.e., Hantavirus, Orthobunyavirus, Nairovirus, Tospovirus, and Phlebovirus). Many of these viruses are significant human or agricultural pathogens.
Pierre-Yves Lozach, Jane Tao
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mSphere, 2017 In recent years, several newly discovered tick-borne viruses causing a wide spectrum of diseases in humans have been ascribed to the Phlebovirus genus of the Bunyaviridae family.
Veronica V. Rezelj +5 more
doaj +1 more source
Interferon-stimulated gene (ISG)-expression screening reveals the specific antibunyaviral activity of ISG20 [PDF]
, 2018 Bunyaviruses pose a significant threat to human health, prosperity and food security. In response to viral infections, interferons (IFNs) upregulate the expression of hundreds of interferon stimulated genes (ISGs) whose cumulative action can potently ...
Bieniasz, Paul D. +15 more
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Transcription of a Recombinant Bunyavirus RNA Template by Transiently Expressed Bunyavirus Proteins
Virology, 1995 We describe a convenient system for analyzing bunyavirus transcription using a recombinant RNA template derived from the plasmid pBUNSCAT, which comprises a negative-sense reporter gene (chloramphenicol acetyltransferase or CAT) flanked by the exact 5' and 3' untranslated regions of the Bunyamwera virus (BUN) S RNA segment.
Dunn, Ewan F. +3 more
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Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism [PDF]
, 2013 Schmallenberg virus (SBV) is a newly emerged orthobunyavirus (family Bunyaviridae) that has caused severe disease in the offspring of farm animals across Europe.
Bottcher, B. +4 more
core +1 more source