Results 51 to 60 of about 4,622 (197)

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

Structural studies of bunyavirus interferon antagonist proteins [PDF]

, 2016
Bunyaviridae is one of the biggest known viral families, and includes many viruses of clinical and economic importance. The major virulence factor of most bunyaviruses is the non-structural protein (NSs).
Barski, Michał S.
core   +1 more source

Mechanistic insight into the efficient packaging of antigenomic S RNA into Rift Valley fever virus particles

Frontiers in Cellular and Infection Microbiology, 2023
Rift Valley fever virus (RVFV), a bunyavirus, has a single-stranded, negative-sense tri-segmented RNA genome, consisting of L, M and S RNAs. An infectious virion carries two envelope glycoproteins, Gn and Gc, along with ribonucleoprotein complexes ...
Breanna Tercero, Kaori Terasaki, Kaori Terasaki, Krishna Narayanan, Shinji Makino, Shinji Makino, Shinji Makino, Shinji Makino, Shinji Makino   +8 more
doaj   +1 more source

Multiple Reassortments, Limited Geographic Spread, and Comparable Pathogenicity of Crimean‐Congo Hemorrhagic Fever Viruses in Sivas Province, Türkiye

Journal of Medical Virology, Volume 98, Issue 6, June 2026.
ABSTRACT Crimean‐Congo hemorrhagic fever virus (CCHFV) is a segmented RNA virus that can cause severe hemorrhagic fever and is primarily transmitted to humans and other mammals through tick bites. Since segment reassortment can increase genetic diversity and disease severity, we sampled infected ticks and humans in Sivas Province, Türkiye, a region ...
Qianying Lin, Nazif Elaldi, Mesut Yigit, Baris Yildiz, Roger Hewson, Martín López‐García, Grant Lythe, Ayse Nur Pektas, Binnur Koksal, Tuba Nur Tasseten, Ahmet Deniz, Hilal Bedir, Yasemin Cakir Kiymaz, Zati Vatansever, Carmen Molina‐París, Thomas Leitner   +15 more
wiley   +1 more source

Innate immunity shapes the persistent transmission of plant viruses by insect vectors

New Plant Protection, Volume 3, Issue 2, June 2026.
In this review, we focus on two key aspects of the virus–vector interplay: (1) persistently transmitted viruses utilize host factors to overcome transmission barriers; and (2) molecular recognition activates antiviral immunity and subsequent viral counter‐defense. Understanding these interactions offers critical insights for developing novel strategies
Gang Lu, Chuanxi Zhang, Junmin Li
wiley   +1 more source

The Dissemination of Rift Valley Fever Virus to the Eye and Sensory Neurons of Zebrafish Larvae Is Stat1-Dependent

Viruses
The Rift Valley fever virus (RVFV) causes haemorrhagic fever, encephalitis, and permanent blindness and has been listed by the WHO as a priority pathogen.
Sebastiaan ter Horst, Aleksandra Siekierska, Ann-Sofie De Meulemeester, Arno Cuvry, Laura Cools, Johan Neyts, Peter de Witte, Joana Rocha-Pereira   +7 more
doaj   +1 more source

Preliminary Evaluation of a Bunyavirus Vector for Cancer Immunotherapy [PDF]

Journal of Virology, 2015
ABSTRACT Replicon particles of Rift Valley fever virus, referred to as nonspreading Rift Valley fever virus (NSR), are intrinsically safe and highly immunogenic. Here, we demonstrate that NSR-infected human dendritic cells can activate CD8 + T cells in vitro and that prophylactic ...
Oreshkova, N.D., Spel, L., Vloet, R.P.M., Wichgers Schreur, P.J., Moormann, R.J.M., Boes, M., Kortekaas, J.A.   +6 more
openaire   +2 more sources

Extending the Targets for Coronavirus Antivirals Beyond That of Approved Drugs: Insights From Preclinical Research

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
Chemical structure of RIBOTAC inhibitor with metabolic handle binding as nucleotide analogue to SARS‐CoV‐2 RNA dependent RNA polymerase, its linker and the RNase L recruiter which binds RNase L monomers and mediates their dimerization that actives nuclease activity degrading the viral RNA.
Harald Brüssow
wiley   +1 more source

The Rice Stripe Virus p2 Interacts With Lsm1 and Disrupts the Lsm1‐Lsm4 Complex to Facilitate the Viral infection

Molecular Plant Pathology, Volume 27, Issue 5, May 2026.
RSV p2 binds Lsm1, disrupting Lsm1‐Lsm4 association and impairing decapping‐dependent mRNA decay in P‐bodies, leading to the accumulation of unstable mRNAs and enhanced RSV infection. ABSTRACT Processing bodies (P‐bodies) play central roles in RNA metabolism and in the regulation of viral infection.
Anqi Hu, Zizhou Zhao, Minjie Shen, Yi Chen, Ying Chen, Miaomiao Li, Lin Lin, Hongying Zheng, Jiejun Peng, Yan Liang, Jianping Chen, Fei Yan, Yuwen Lu   +12 more
wiley   +1 more source

Uncovering Bunyavirus-Host Interactions [PDF]

, 2016
Bunyaviruses are a large family of enveloped RNA viruses that are distributed globally and include many important human and agricultural pathogens. Compared with other pathogenic viruses, bunyaviruses are relatively understudied.
Drake, Mary Jane
core