Results 51 to 60 of about 839 (154)

Phenotype-driven chemical screening in zebrafish for compounds that inhibit collective cell migration identifies multiple pathways potentially involved in metastatic invasion

Disease Models & Mechanisms, 2015
In the last decade, high-throughput chemical screening has become the dominant approach for discovering novel compounds with therapeutic properties. Automated screening using in vitro or cultured cell assays have yielded thousands of candidate drugs for ...
Viviana E. Gallardo, Gaurav K. Varshney, Minnkyong Lee, Sujata Bupp, Lisha Xu, Paul Shinn, Nigel P. Crawford, James Inglese, Shawn M. Burgess   +8 more
doaj   +1 more source

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, Volume 13, Issue 22, 17 April 2026.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

Gut and liver fat metabolism in depancreatized dogs: effects of exercise and acute insulin infusion [PDF]

, 1997
Namdaran, Kiarash, Deanna P. Bracy, D. Brooks Lacy, Janice L. Johnson, Jennifer L. Bupp, and David H. Wasserman. Gut and liver fat metabolism in depancreatized dogs: effects of exercise and acute insulin infusion. J. Appl. Physiol. 83(4): 1339–1347, 1997.
Jennifer L. Bupp, Kiarash Namdaran, Deanna P. Bracy, D. Brooks Lacy, Janice L. Johnson, David H. Wasserman   +5 more
core   +1 more source

Physical Fitness Dynamics Shape Immune Remodeling in Healthy Aging: A 3‐Year Longitudinal Study

Aging Cell, Volume 25, Issue 3, March 2026.
In a 3‐year longitudinal study of healthy older adults, intraindividual declines in physical fitness and strength were linked to dynamic immune remodeling, including shifts toward senescent and regulatory T cell phenotypes, despite stable activity levels.
Christopher Weyh, Vincent Größer, Luciele Guerra Minuzzi, Torsten Frech, Kristina Gebhardt, Svenja Nolte, Theresa Dombrowski, Manuela Andrea Hoffmann, Natascha Sommer, Robert Ringseis, Klaus Eder, Samuel Sossalla, Pascal Bauer, Karsten Krüger   +13 more
wiley   +1 more source

A Collaborative Approach to Pediatric Genetic Evaluation in the Era of Genomic Medicine

American Journal of Medical Genetics Part A, Volume 200, Issue 2, Page 371-378, February 2026.
ABSTRACT To address the increased demand for genetic services and shortage of medical geneticists (MG), a collaborative pilot program was developed with a two‐part approach to care: (1) Initial genetic counselor (GC) appointment with exome sequencing (ES) and (2) follow‐up MG evaluation.
Sarah Jurgensmeyer Langas, Allison Goetsch Weisman, Valerie Allegretti, Katherine Kim, Roxanne Birriel, Carlos E. Prada   +5 more
wiley   +1 more source

When Heather needs her second mommy

Juvenile &Family Court Journal, Volume 76, Issue 4, Page 4-25, December 2025.
Abstract Obergefell v. Hodges, 576 U.S. 644 (2015) appeared to settle certain issues in family law by allowing same gender individuals to marry. Unfortunately, Obergefell left some areas of inequality between same gender and heterogeneous households, including visitation and family support rights and obligations, especially rights outside of and before
Daniel R. Fruit
wiley   +1 more source

CD4+ differentiated T regulatory cells is modified by physical fitness and visceral adipose tissue in young adults—A cross‐sectional study

Physiological Reports, Volume 13, Issue 16, August 2025.
High cardiorespiratory fitness and low visceral adiposity modulate CD4+ T regulatory cells. Fit participants shows be more responsible to mTORC1/2 inhibition via rapamycin or Torin‐1indicating a fitness‐ and adiposity‐dependent immunometabolic regulation.
Camila S. Padilha, Tiago Olean‐Oliveira, Caique Figueiredo, Vanessa R. Dos Santos, Gilson P. Dorneles, José Procópio Jabur Ribeiro, Rafael Deminice, Karsten Krüger, José C. Rosa‐Neto, Fábio S. Lira   +9 more
wiley   +1 more source

Strength in Numbers: How Social Resources Travel Together to Increase Employee Engagement

Asia Pacific Journal of Human Resources, Volume 63, Issue 2, April 2025.
ABSTRACT Based on a 2021 survey of 273 Australian workers across a range of occupations and industries, our structural equation modelling showed that workplace inclusion is a key driver of social resources for building employee engagement within the organisation.
Peter A. Murray, Kim Southey, Marnie Gibson, John Sands, Derek Ong   +4 more
wiley   +1 more source

John Lydgate and His Readers [PDF]

, 2018
Fifteenth-century poet John Lydgate holds the distinction of being both prolific and popular in his own time. Unfortunate comparisons to his literary forbear, Geoffrey Chaucer, dampened his early reputation, and Lydgate spent centuries out of favor with ...
Bupp, Alaina
core   +3 more sources

Examining Roles, Challenges, and Opportunities Within the Metabolic Genetics Workforce

American Journal of Medical Genetics Part A, Volume 197, Issue 2, February 2025.
ABSTRACT The metabolic genetics clinic is a crucial hub for the management of patients with inborn errors of metabolism and other complex genetic conditions. Because more patients are being identified due to the expanded diagnostics, including newborn screening, and living longer with the advent of improved therapies, the multidisciplinary metabolic ...
Kara Simpson, Stephanie Offord, Chanel Suares, Jerry Vockley   +3 more
wiley   +1 more source