Royal Society Open Science, 2021 Eflornithine (EFN) is an anti-Trypanosoma brucei agent for the medication of sleeping sickness and widely distributed for the treatment of hirsutism (unwanted facial hair in women).
Mohamed A Abdel-Lateef +1 more
exaly +3 more sources
Identification of transport systems involved in eflornithine delivery across the blood-brain barrier [PDF]
Frontiers in Drug Delivery, 2023 Human African Trypanosomiasis (HAT) is a neglected parasitic disease that continues to persist in sub-Saharan Africa. It is fatal if untreated. The first stage of the disease is associated with the presence of the parasite in the periphery and the second
Christopher P. Watson +2 more
doaj +2 more sources
Enantiospecific antitrypanosomal in vitro activity of eflornithine.
PLoS Neglected Tropical Diseases, 2021 The polyamine synthesis inhibitor eflornithine is a recommended treatment for the neglected tropical disease Gambian human African trypanosomiasis in late stage.
Mikael Boberg +5 more
doaj +4 more sources
A molecular mechanism for eflornithine resistance in African trypanosomes. [PDF]
PLoS Pathogens, 2010 Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the protozoan parasite Trypanosoma brucei.
Isabel M Vincent +7 more
doaj +6 more sources
The impact of thermophysical properties on eflornithine drug solute in acetone and ethyl acetate solvent interactions at varying concentrations and temperatures [PDF]
BMC ChemistryThe study was conducted on the impact of thermophysical properties on eflornithine drug solute–solvent interactions in aqueous ethyl acetate and acetone at different concentrations and temperatures.
Dereje Fedasa Tegegn, Shuma Fayera Wirtu
doaj +2 more sources
Conformational analysis of difluoromethylornithine: factors influencing its gas-phase and bioactive conformations [PDF]
Beilstein Journal of Organic ChemistryDifluoromethylornithine (DFMO, eflornithine) is a fluorinated analogue of ornithine that serves both as an inhibitor of ornithine decarboxylase and as a therapeutic agent against African trypanosomiasis.
Matheus P. Freitas
doaj +2 more sources
Evolution, composition and functions of cullin E3 ubiquitin ligases in trypanosomes [PDF]
Scientific ReportsPost-translational modifications (PTMs) modulate protein functions, with ubiquitylation a pre-eminent example, and playing major roles in protein turnover.
Ricardo Canavate del Pino +3 more
doaj +2 more sources
ARID1A deficiency-driven reprogramming of polyamine metabolism promotes endometrial cancer malignancy and immune escape [PDF]
Cell Death and DiseaseMetabolic reprogramming is crucial in developing endometrial cancer (EC); however, the mechanisms through which tumor suppressors control metabolites that drive cell proliferation and tumor growth remain unclear.
Han Tao +7 more
doaj +2 more sources
Frontiers in Chemistry, 2021 Targeting the polyamine biosynthetic pathway by inhibiting ornithine decarboxylase (ODC) is a powerful approach in the fight against diverse viruses, including SARS-CoV-2.
Joanna Bojarska +8 more
doaj +1 more source
An Update on African Trypanocide Pharmaceutics and Resistance
Frontiers in Veterinary Science, 2022 African trypanosomiasis is associated with Trypanosoma evansi, T. vivax, T. congolense, and T. brucei pathogens in African animal trypanosomiasis (AAT) while T. b gambiense and T.
Keneth Iceland Kasozi +5 more
doaj +1 more source