Results 1 to 10 of about 2,541 (192)

A molecular mechanism for eflornithine resistance in African trypanosomes. [PDF]

PLoS Pathogens, 2010
Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the protozoan parasite Trypanosoma brucei.
Isabel M Vincent, Darren Creek, David G Watson, Mohammed A Kamleh, Debra J Woods, Pui Ee Wong, Richard J S Burchmore, Michael P Barrett   +7 more
doaj   +12 more sources

Enantiospecific antitrypanosomal in vitro activity of eflornithine. [PDF]

PLoS Neglected Tropical Diseases, 2021
The polyamine synthesis inhibitor eflornithine is a recommended treatment for the neglected tropical disease Gambian human African trypanosomiasis in late stage.
Mikael Boberg, Monica Cal, Marcel Kaiser, Rasmus Jansson-Löfmark, Pascal Mäser, Michael Ashton   +5 more
doaj   +6 more sources

Application of Hantzsch Reaction for Sensitive Determination of Eflornithine in Cream, Plasma and Urine Samples

Royal Society Open Science, 2021
Eflornithine (EFN) is an anti-Trypanosoma brucei agent for the medication of sleeping sickness and widely distributed for the treatment of hirsutism (unwanted facial hair in women).
Mohamed A Abdel-Lateef, Albandary Al Mahri   +1 more
exaly   +3 more sources

Identification of transport systems involved in eflornithine delivery across the blood-brain barrier [PDF]

Frontiers in Drug Delivery, 2023
Human African Trypanosomiasis (HAT) is a neglected parasitic disease that continues to persist in sub-Saharan Africa. It is fatal if untreated. The first stage of the disease is associated with the presence of the parasite in the periphery and the second
Christopher P. Watson, Gayathri Nair Sekhar, Sarah A. Thomas   +2 more
doaj   +2 more sources

The impact of thermophysical properties on eflornithine drug solute in acetone and ethyl acetate solvent interactions at varying concentrations and temperatures [PDF]

BMC Chemistry
The study was conducted on the impact of thermophysical properties on eflornithine drug solute–solvent interactions in aqueous ethyl acetate and acetone at different concentrations and temperatures.
Dereje Fedasa Tegegn, Shuma Fayera Wirtu
doaj   +2 more sources

Conformational analysis of difluoromethylornithine: factors influencing its gas-phase and bioactive conformations [PDF]

Beilstein Journal of Organic Chemistry
Difluoromethylornithine (DFMO, eflornithine) is a fluorinated analogue of ornithine that serves both as an inhibitor of ornithine decarboxylase and as a therapeutic agent against African trypanosomiasis.
Matheus P. Freitas
doaj   +2 more sources

Eflornithine for Chemoprevention in the High-Risk Population of Colorectal Cancer: A Systematic Review and Meta-Analysis With Trial Sequential Analysis

Frontiers in Oncology, 2023
ObjectivesTo evaluate the efficacy of Difluoromethylornithine (DFMO) chemoprevention in the high-risk population for colorectal cancer (CRC).MethodsMeta-analysis was conducted to assess the caliber of the included literature by searching five databases ...
Shasha Hu
exaly   +3 more sources

Evolution, composition and functions of cullin E3 ubiquitin ligases in trypanosomes [PDF]

Scientific Reports
Post-translational modifications (PTMs) modulate protein functions, with ubiquitylation a pre-eminent example, and playing major roles in protein turnover.
Ricardo Canavate del Pino, Martin Zoltner, Erin R. Butterfield, Mark C. Field   +3 more
doaj   +2 more sources

Eflornithine for neuroblastoma. [PDF]

Aust Prescr
europepmc   +5 more sources

The First Insight Into the Supramolecular System of D,L-α-Difluoromethylornithine: A New Antiviral Perspective

Frontiers in Chemistry, 2021
Targeting the polyamine biosynthetic pathway by inhibiting ornithine decarboxylase (ODC) is a powerful approach in the fight against diverse viruses, including SARS-CoV-2.
Joanna Bojarska, Roger New, Paweł Borowiecki, Milan Remko, Martin Breza, Izabela D. Madura, Andrzej Fruziński, Anna Pietrzak, Wojciech M. Wolf   +8 more
doaj   +1 more source