Results 31 to 40 of about 2,541 (192)

Alpha-Difluoromethylornithine, an Irreversible Inhibitor of Polyamine Biosynthesis, as a Therapeutic Strategy against Hyperproliferative and Infectious Diseases

Medical Sciences, 2018
The fluorinated ornithine analog α-difluoromethylornithine (DFMO, eflornithine, ornidyl) is an irreversible suicide inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme of polyamine biosynthesis.
Nicole LoGiudice, Linh Le, Irene Abuan, Yvette Leizorek, Sigrid C. Roberts   +4 more
doaj   +1 more source

Eflornithine is a cost-effective alternative to melarsoprol for the treatment of second-stage human West African trypanosomiasis in Caxito, Angola. [PDF]

, 2008
OBJECTIVE: To compare the cost-effectiveness of eflornithine and melarsoprol in the treatment of human African trypanosomiasis. METHOD: We used data from a Médecins Sans Frontières treatment project in Caxito, Angola to do a formal cost-effectiveness ...
Boelaert, M, Robays, J, T. Josenando, Josenando, T., Raguenaud, M E, M. E. Raguenaud, Josenando, T, Boelaert, M., Robays, J., M. Boelaert, Raguenaud, M. E., J. Robays   +11 more
core   +1 more source

Eflornithin [PDF]

pharma-kritik, 2009
Ein Ornithindekarboxylasehemmer, der in Form einer Crème bei Gesichtshirsutismus lokal appliziert werden kann. Bei etwa einem Drittel der behandelten Frauen lässt sich ein guter Erfolg erreichen, doch muss die Behandlung ständig weitergeführt werden.
openaire   +1 more source

Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model. [PDF]

PLoS Neglected Tropical Diseases, 2016
Trypanosoma brucei gambiense is the main causative agent of Human African Trypanosomiasis (HAT), also known as sleeping sickness. Because of limited alternatives and treatment toxicities, new therapeutic options are urgently needed for patients with HAT.
Frédéric-Antoine Dauchy, Mélanie Bonhivers, Nicolas Landrein, Denis Dacheux, Pierrette Courtois, Florian Lauruol, Sylvie Daulouède, Philippe Vincendeau, Derrick R Robinson   +8 more
doaj   +1 more source

Recent progress in diagnosis and treatment of Human African Trypanosomiasis has made the elimination of this disease a realistic target by 2030

Frontiers in Medicine, 2022
Human African Trypanosomiasis (HAT) is caused by unicellular flagellated protozoan parasites of the genus Trypanosoma brucei. The subspecies T. b. gambiense is mainly responsible for mostly chronic anthroponotic infections in West- and Central Africa ...
Andrés Álvarez-Rodríguez, Andrés Álvarez-Rodríguez, Bo-Kyung Jin, Magdalena Radwanska, Magdalena Radwanska, Stefan Magez, Stefan Magez, Stefan Magez   +7 more
doaj   +1 more source

The development of drugs for treatment of sleeping sickness: a historical review

Parasites & Vectors, 2010
Only four drugs are available for the chemotherapy of human African trypanosomiasis or sleeping sickness; Suramin, pentamidine, melarsoprol and eflornithine. The history of the development of these drugs is well known and documented. suramin, pentamidine
Steverding Dietmar
doaj   +1 more source

Eflornithine is Safer Than Melarsoprol for the Treatment of Second-Stage Trypanosoma Brucei Gambiense Human African Trypanosomiasis. [PDF]

, 2005
Patients with second-stage human African trypanosomiasis treated with eflornithine (n = 251) in 2003 in Kiri, southern Sudan, had an adjusted relative risk of death of 0.2 and experienced significantly fewer cutaneous and neurological adverse effects ...
Chappuis, F, Udayraj, N, Meussen, A, Bovier, P A, Stietenroth, K, Meussen A, Bovier PA, Chappuis F, Udayraj N, Stietenroth K   +9 more
core   +1 more source

Principles of management of women with hirsutism – a dermatologist’s perspective

Przegląd Dermatologiczny, 2020
Hirsutism is a common clinical diagnosis defined by the presence of excess growth of terminal hair in androgen-sensitive areas. It affects 5–15% of women, often having a significant impact on their daily functioning. Hirsutism is mainly caused by ovarian
Dominik Mikiel, Barbara Olszewska, Adriana Polańska, Zygmunt Adamski, Ryszard Żaba, Aleksandra Dańczak-Pazdrowska   +5 more
doaj   +1 more source

Potentials of curcumin against polycystic ovary syndrome: Pharmacological insights and therapeutic promises

Heliyon, 2023
Polycystic ovary syndrome (PCOS) is a common hormonal disorder among women (4%–20%) when the ovaries create abnormally high levels of androgens, the male sex hormones that are typically present in women in trace amounts.
Tanzina Akter, Md. Sarwar Zahan, Nafisa Nawal, Md. Hasanur Rahman, Tayyabatun Nur Tanjum, Kazi Ifthi Arafat, Akhi Moni, Mohammad Nazrul Islam, Md Jamal Uddin   +8 more
doaj   +1 more source

Eflornithine Hydrochloride-Loaded Electrospun Nanofibers as a Potential Face Mask for Hirsutism Application

Pharmaceutics, 2023
Hirsutism is a distressing condition that can affect women’s self-esteem due to the excessive amount of hair growth in different body parts, including the face. A temporary managing option is to develop a self-care routine to remove unwanted hair through
Shuruq S. Almuwallad, Dunia A. Alzahrani, Walaa S. Aburayan, Ahmed J. Alfahad, Khulud A. Alsulami, Alhassan H. Aodah, Samar A. Alsudir, Sulaiman S. Alhudaithi, Essam A. Tawfik   +8 more
doaj   +1 more source