Results 31 to 40 of about 2,011 (166)

Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei.

PLoS Neglected Tropical Diseases, 2012
A non-targeted metabolomics-based approach is presented that enables the study of pathways in response to drug action with the aim of defining the mode of action of trypanocides.
Isabel M Vincent, Darren J Creek, Karl Burgess, Debra J Woods, Richard J S Burchmore, Michael P Barrett   +5 more
doaj   +1 more source

ODC-Driven Polyamines Synthesis Sustains the Self-Renewal of Glioblastoma Stem Cells and Drives Tumor Aggressiveness. [PDF]

Cancer Sci
Our findings delineate a novel regulatory network that integrates metabolic and GSCs self‐renewal in GBM. By integrating genetic ODC ablation with multiomic profiling, we redefine polyamine metabolism as a linchpin of GSCs self‐renewal, a dependency exploitable through precision gene editing.
Wei XC, Zhang HQ, Liu GQ, Liu CW, Li AL, Pan X, Yan WQ, Chen JY.   +7 more
europepmc   +2 more sources

Comparison of the Pharmacokinetics of Eflornithine after Application of Eflornithine Cream and “Eflornithine: Armenicum” Composition in Rates

, 2023
This chapter reports the study results to determine percutaneous absorption and pharmacokinetics of eflornithine following topical treatment with eflornithine hydrochloride 13.9% cream and “eflornithine–armenicum” composition in rats. The model of aerobic wounds was developed. Eflornithine hydrochloride cream (dose of 460 mg/kg) was applied in group I,
Hovhannes Ghazaryan, Areg Hovhannisyan
openaire   +1 more source

Eflornithine Hydrochloride-Loaded Electrospun Nanofibers as a Potential Face Mask for Hirsutism Application

Pharmaceutics, 2023
Hirsutism is a distressing condition that can affect women’s self-esteem due to the excessive amount of hair growth in different body parts, including the face. A temporary managing option is to develop a self-care routine to remove unwanted hair through
Shuruq S. Almuwallad, Dunia A. Alzahrani, Walaa S. Aburayan, Ahmed J. Alfahad, Khulud A. Alsulami, Alhassan H. Aodah, Samar A. Alsudir, Sulaiman S. Alhudaithi, Essam A. Tawfik   +8 more
doaj   +1 more source

Sustainable Multi-Target Drugs for Neglected Tropical Diseases Caused by Trypanosomatids: Dream or Reality?

Proceedings, 2017
The development of nifurtimox-eflornithine combination therapy (NECT) has been a major and emboldening advance towards more effective and simple medications in the field of neglected tropical diseases (NTD) caused by Trypanosomatids. [...]
Maria Laura Bolognesi
doaj   +1 more source

Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawal. [PDF]

PLoS Neglected Tropical Diseases, 2009
BackgroundThe development of arsenical and diamidine resistance in Trypanosoma brucei is associated with loss of drug uptake by the P2 purine transporter as a result of alterations in the corresponding T.
Anne J N Kazibwe, Barbara Nerima, Harry P de Koning, Pascal Mäser, Michael P Barrett, Enock Matovu   +5 more
doaj   +1 more source

Identification of clinically approved small molecules that inhibit growth and affect transcript levels of developmentally regulated genes in the African trypanosome.

PLoS Neglected Tropical Diseases, 2020
Trypanosoma brucei are unicellular parasites endemic to Sub-Saharan Africa that cause fatal disease in humans and animals. Infection with these parasites is caused by the bite of the tsetse fly vector, and parasites living extracellularly in the blood of
Madison Elle Walsh, Eleanor Mary Naudzius, Savanah Jessica Diaz, Theodore William Wismar, Mikhail Martchenko Shilman, Danae Schulz   +5 more
doaj   +1 more source

Inhibition of Ornithine Decarboxylase 1 Mitigates Denervation‐Induced Muscle Atrophy by Suppressing Proteolysis and Preserving Muscle Stem Cell Homeostasis

Cell Proliferation, EarlyView.
Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Mingming Zhang, Feifan Chang, Siliang Ge, Fuming Cao, Pincong Fu, Haobo Zhang, Ming Chen, Yi Li, Peifu Tang, Pengbin Yin   +9 more
wiley   +1 more source

Human African trypanosomiasis caused by Trypanosoma brucei gambiense: The first case report in China

International Journal of Infectious Diseases, 2019
We report the first imported case in China of human African trypanosomiasis (HAT), caused by Trypanosoma brucei gambiense, in a sailor returning from Gabon in 2014.
Nian Chen, Ke Jin, Jingjing Xu, Jianfu Zhang, Yali Weng   +4 more
doaj   +1 more source

Satellite Glial Cells Synthesize and Release GABA to Activate Extrasynaptic GABAA Receptors That Modulate Dorsal Root Ganglia Neuron Excitability

Glia, Volume 74, Issue 9, September 2026.
Mechanism of synthesis, release, receptor activation, uptake, and degradation of GABA in dorsal root ganglia (DRG). Left: GABA is synthesized from putrescine in satellite glial cells (SGCs). After being released by Best1 channel, it activates GABAA receptors in sensory neurons, producing a chloride current.
Natalie Jiménez‐Barrios, Ricardo González‐Ramírez, Francisco Javier Paz‐Bermúdez, Guadalupe Raya‐Tafolla, José Segovia Vila, Ricardo Felix, Rodolfo Delgado‐Lezama, Benjamín Florán Garduño   +7 more
wiley   +1 more source