Results 11 to 20 of about 2,541 (192)

Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei. [PDF]

PLoS Neglected Tropical Diseases, 2012
A non-targeted metabolomics-based approach is presented that enables the study of pathways in response to drug action with the aim of defining the mode of action of trypanocides.
Isabel M Vincent, Darren J Creek, Karl Burgess, Debra J Woods, Richard J S Burchmore, Michael P Barrett   +5 more
doaj   +4 more sources

Nifurtimox plus Eflornithine for late-stage sleeping sickness in Uganda: a case series. [PDF]

PLoS Neglected Tropical Diseases, 2007
We report efficacy and safety outcomes from a prospective case series of 31 late-stage T.b. gambiense sleeping sickness (Human African Trypanosomiasis, HAT) patients treated with a combination of nifurtimox and eflornithine (N+E) in Yumbe, northwest ...
Francesco Checchi, Patrice Piola, Harriet Ayikoru, Florence Thomas, Dominique Legros, Gerardo Priotto   +5 more
doaj   +3 more sources

In-hospital safety in field conditions of nifurtimox eflornithine combination therapy (NECT) for T. b. gambiense sleeping sickness. [PDF]

PLoS Neglected Tropical Diseases, 2012
BackgroundTrypanosoma brucei (T.b.) gambiense Human African trypanosomiasis (HAT; sleeping sickness) is a fatal disease. Until 2009, available treatments for 2(nd) stage HAT were complicated to use, expensive (eflornithine monotherapy), or toxic, and ...
Caecilia Schmid, Andrea Kuemmerle, Johannes Blum, Salah Ghabri, Victor Kande, Wilfried Mutombo, Medard Ilunga, Ismael Lumpungu, Sylvain Mutanda, Pathou Nganzobo, Digas Tete, Nono Mubwa, Mays Kisala, Severine Blesson, Olaf Valverde Mordt   +14 more
doaj   +2 more sources

Melarsoprol versus eflornithine for treating late-stage Gambian trypanosomiasis in the Republic of the Congo [PDF]

Bulletin of the World Health Organization, 2006
OBJECTIVE: To compare the effectiveness of melarsoprol and eflornithine in treating late-stage Gambian trypanosomiasis in the Republic of the Congo. METHODS: We analysed the outcomes of death during treatment and relapse within 1 year of discharge for ...
Manica Balasegaram, Steve Harris, Francesco Checchi, Sara Ghorashian, Catherine Hamel, Unni Karunakara   +5 more
doaj   +2 more sources

Enantioselective and Nonlinear Intestinal Absorption of Eflornithine in the Rat [PDF]

Antimicrobial Agents and Chemotherapy, 2008
ABSTRACTThis study aimed to investigate if the absorption of the human African trypanosomiasis agent eflornithine was stereospecific and dose dependent after oral administration. Male Sprague-Dawley rats were administered single doses of racemic eflornithine hydrochloride as an oral solution (750, 1,500, 2,000, or 3,000 mg/kg of body weight) or ...
R, Jansson, M, Malm, C, Roth, M, Ashton
openaire   +3 more sources

A Role for Janus Cyclohexyl Ring Motifs in Medicinal Chemistry. Incorporation Into G-Quadruplex Ligands and Anti-Trypanosoma brucei Activity. [PDF]

Chembiochem
Naphthalene diimide (NDI) cores with peripheral fluorocyclohexyl ring systems are explored binding to G‐quadruplex DNA and were also assayed against the Trypanosoma brucei parasite. The most active compound of the series displayed nanomolar activity and suggested electrostatic interactions between the polarized cyclohexane and G‐Quad DNA.
Stewart JM, Kehler M, Kuodis V, Parkinson GN, Chen W, Smith TK, Waller ZAE, O'Hagan D.   +7 more
europepmc   +2 more sources

Chiral Chromatographic Isolation on Milligram Scale of the Human African Trypanosomiasis Treatment d- and l‑Eflornithine [PDF]

ACS Omega, 2020
Human African trypanosomiasis is a fatal disease unless treated. It is a parasitic vector borne disease endemic in sub-Saharan African countries. Eflornithine is a recommended treatment for gambiense human African trypanosomiasis (g-HAT) in the later ...
Mikael Boberg, Anna C. Jonson, Hanna Leek, Rasmus Jansson-Löfmark, Michael Ashton   +4 more
doaj   +3 more sources

Pathogenic Significance of Trypanosomatids: Progress in Drug Resistance, Control Strategies, and Artificial Intelligence. [PDF]

Interdiscip Perspect Infect Dis
Trypanosomatids, including the genera Trypanosoma and Leishmania, are protozoan parasites of significant medical and veterinary relevance. These organisms cause African trypanosomiasis, Chagas disease, and leishmaniasis, which are classified as neglected tropical diseases (NTDs).
Amisigo CM, Dofuor AK, Dofuor AK, Yamoah JAA, Aiduenu AF, Gayi BK, Akomea A, Alidu ZL, Danso G, Ayivi-Tosuh SM, Quartey NK, Osei JHN, Loh SK, Ekloh W.   +13 more
europepmc   +2 more sources

Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review. [PDF]

Am J Med Genet A
ABSTRACT Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...
VanSickle EA, Sarasua SM, Lowe T, Farrell CL, Boccuto L, Schwartz C, Pegg AE, Peron A, Faundes V, Ganapathi M, Chung WK, Ziegler A, Hofstede F, Prouteau C, Steindl K, Olson C, Devinsky O, Mastracci TL, Casero RA, Stewart TM, Gilmour S, Koerner T, Kutler MJ, Rajasekaran S, Michael J, Bachmann AS, Bupp CP.   +26 more
europepmc   +2 more sources

An Update on African Trypanocide Pharmaceutics and Resistance

Frontiers in Veterinary Science, 2022
African trypanosomiasis is associated with Trypanosoma evansi, T. vivax, T. congolense, and T. brucei pathogens in African animal trypanosomiasis (AAT) while T. b gambiense and T.
Keneth Iceland Kasozi, Keneth Iceland Kasozi, Ewan Thomas MacLeod, Ibrahim Ntulume, Susan Christina Welburn, Susan Christina Welburn   +5 more
doaj   +1 more source