Results 11 to 20 of about 1,936 (110)

Repurposing eflornithine to treat a patient with a rare ODC1 gain-of-function variant disease

eLife, 2021
Background: Polyamine levels are intricately controlled by biosynthetic, catabolic enzymes and antizymes. The complexity suggests that minute alterations in levels lead to profound abnormalities.
Surender Rajasekaran, Caleb P Bupp, Mara Leimanis-Laurens, Ankit Shukla, Christopher Russell, Joseph Junewick, Emily Gleason, Elizabeth A VanSickle, Yvonne Edgerly, Bryan M Wittmann, Jeremy W Prokop, André S Bachmann   +11 more
doaj   +1 more source

Effectiveness of Nifurtimox Eflornithine Combination Therapy (NECT) in T. b. gambiense second stage sleeping sickness patients in the Democratic Republic of Congo: Report from a field study

PLoS Neglected Tropical Diseases, 2021
Background Nifurtimox-eflornithine combination therapy (NECT) for the treatment of second stage gambiense human African trypanosomiasis (HAT) was added to the World Health Organization’s Essential Medicines List in 2009 after demonstration of its non ...
Andrea Kuemmerle, Caecilia Schmid, Sonja Bernhard, Victor Kande, Wilfried Mutombo, Medard Ilunga, Ismael Lumpungu, Sylvain Mutanda, Pathou Nganzobo, Digas Ngolo Tete, Mays Kisala, Christian Burri, Severine Blesson, Olaf Valverde Mordt   +13 more
doaj   +2 more sources

Systematic Review and Meta-Analysis on Human African Trypanocide Resistance

Pathogens, 2022
Background Human African trypanocide resistance (HATr) is a challenge for the eradication of Human African Trypansomiaisis (HAT) following the widespread emergence of increased monotherapy drug treatment failures against Trypanosoma brucei gambiense and ...
Keneth Iceland Kasozi, Ewan Thomas MacLeod, Susan Christina Welburn   +2 more
doaj   +1 more source

Conformational analysis of difluoromethylornithine: factors influencing its gas-phase and bioactive conformations. [PDF]

Beilstein J Org Chem
Difluoromethylornithine (DFMO, eflornithine) is a fluorinated analogue of ornithine that serves both as an inhibitor of ornithine decarboxylase and as a therapeutic agent against African trypanosomiasis.
Freitas MP.
europepmc   +2 more sources

Evolution, composition and functions of cullin E3 ubiquitin ligases in trypanosomes. [PDF]

Sci Rep
Post-translational modifications (PTMs) modulate protein functions, with ubiquitylation a pre-eminent example, and playing major roles in protein turnover.
Del Pino RC, Zoltner M, Butterfield ER, Field MC.   +3 more
europepmc   +2 more sources

A molecular mechanism for eflornithine resistance in African trypanosomes.

PLoS Pathogens, 2010
Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the protozoan parasite Trypanosoma brucei.
Isabel M Vincent, Darren Creek, David G Watson, Mohammed A Kamleh, Debra J Woods, Pui Ee Wong, Richard J S Burchmore, Michael P Barrett   +7 more
doaj   +1 more source

Clinical importance of eflornithine (α-difluoromethylornithine) for the treatment of malignant gliomas

CNS Oncology, 2018
This review covers the literature between 1989 and 2007 on studies relevant to the neuro-oncology usage of eflornithine (α-difluoromethylornithine), an oral agent that irreversibly inhibits the enzyme ornithine decarboxylase.
Victor A Levin, Sandra E Ictech, Kenneth R Hess   +2 more
doaj   +1 more source

A multicentre, randomised, non-inferiority clinical trial comparing a nifurtimox-eflornithine combination to standard eflornithine monotherapy for late stage Trypanosoma brucei gambiense human African trypanosomiasis in Uganda

Parasites & Vectors, 2018
Background While the combination of nifurtimox and eflornithine (NECT) is currently recommended for the treatment of the late stage human African trypansomiasis (HAT), single-agent eflornithine was still the treatment of choice when this trial commenced.
Freddie Kansiime, Seraphine Adibaku, Charles Wamboga, Franklin Idi, Charles Drago Kato, Lawrence Yamuah, Michel Vaillant, Deborah Kioy, Piero Olliaro, Enock Matovu   +9 more
doaj   +1 more source

Heteroleptic Transition Metal Complexes of Eflornithine Hydrochloride Monohydrate: Synthesis, Characterization, in silico and in vitro Biological Studies

Journal of the Turkish Chemical Society, Section A: Chemistry, 2022
Incessant development of resistance to drugs by microorganisms remains a major setback associated with the currently available antibiotics, thereby making imperative a continuous search for alternative candidates with improved efficacy.
Yusuf AYİPO
doaj   +1 more source

Nifurtimox plus Eflornithine for late-stage sleeping sickness in Uganda: a case series. [PDF]

PLoS Neglected Tropical Diseases, 2007
We report efficacy and safety outcomes from a prospective case series of 31 late-stage T.b. gambiense sleeping sickness (Human African Trypanosomiasis, HAT) patients treated with a combination of nifurtimox and eflornithine (N+E) in Yumbe, northwest ...
Francesco Checchi, Patrice Piola, Harriet Ayikoru, Florence Thomas, Dominique Legros, Gerardo Priotto   +5 more
doaj   +1 more source