On the Stereoselective Pharmacokinetics of Eflornithine and Prediction of Drug Tissue to Plasma Concentration Ratios [PDF]
, 2009 Eflornithine is one of two registered drugs for the treatment of late-stage human African trypanosomiasis, a uniformly fatal neglected disease with sixty million people are at risk of being infected.
Jansson Löfmark, Rasmus
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Proceedings, 2017 The development of nifurtimox-eflornithine combination therapy (NECT) has been a major and emboldening advance towards more effective and simple medications in the field of neglected tropical diseases (NTD) caused by Trypanosomatids. [...]
Maria Laura Bolognesi
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Three drug combinations for late-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Uganda. [PDF]
, 2006 OBJECTIVES: Our objective was to compare the efficacy and safety of three drug combinations for the treatment of late-stage human African trypanosomiasis caused by Trypanosoma brucei gambiense.
Louga, Albino +23 more
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Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawal. [PDF]
PLoS Neglected Tropical Diseases, 2009 BackgroundThe development of arsenical and diamidine resistance in Trypanosoma brucei is associated with loss of drug uptake by the P2 purine transporter as a result of alterations in the corresponding T.
Anne J N Kazibwe +5 more
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Eflornithine for treatment of high-risk neuroblastoma. [PDF]
Trends Pharmacol SciJiang J, Yu Y.
europepmc +3 more sources
, 2023 This chapter reports the study results to determine percutaneous absorption and pharmacokinetics of eflornithine following topical treatment with eflornithine hydrochloride 13.9% cream and “eflornithine–armenicum” composition in rats. The model of aerobic wounds was developed. Eflornithine hydrochloride cream (dose of 460 mg/kg) was applied in group I,
Hovhannes Ghazaryan, Areg Hovhannisyan
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PLoS Neglected Tropical Diseases, 2020 Trypanosoma brucei are unicellular parasites endemic to Sub-Saharan Africa that cause fatal disease in humans and animals. Infection with these parasites is caused by the bite of the tsetse fly vector, and parasites living extracellularly in the blood of
Madison Elle Walsh +5 more
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From sentinel surveillance for sleeping sickness treatment failure to the development of a pharmacovigilance approach [PDF]
, 2011 In the late 1990’s a disturbing trend of geographically distinct melarsoprol treatment failures accompanied a dramatic resurgence of Human African Trypanosomiasis.
Dahl, Benjamin Arthur
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Human African trypanosomiasis caused by Trypanosoma brucei gambiense: The first case report in China
International Journal of Infectious Diseases, 2019 We report the first imported case in China of human African trypanosomiasis (HAT), caused by Trypanosoma brucei gambiense, in a sailor returning from Gabon in 2014.
Nian Chen +4 more
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Regulatory harmonization: Evolution, globalization and future directions
British Journal of Clinical Pharmacology, EarlyView.Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm +2 more
wiley +1 more source