Results 41 to 50 of about 2,011 (166)

Polycystic ovarian syndrome-current pharmacotherapy and clinical implications

Taiwanese Journal of Obstetrics & Gynecology, 2022
Polycystic ovary syndrome (PCOS), the most common endocrinopathy in women is characterized by polycystic ovaries, chronic anovulation and hyperandrogenism.
Rumaisa Rashid, Suhail Ahmad Mir, Ozaifa Kareem, Tabassum Ali, Rifat Ara, Anjum Malik, Fiza Amin, G.N. Bader   +7 more
doaj   +1 more source

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, Volume 150, Issue 7, Page 990-1015, August 2026.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source

Accelerating Pediatric Oncology Drug Development: Advances in Clinical Pharmacology, Trial Design, Non‐Clinical Evidence, and Regulatory Science

The Journal of Clinical Pharmacology, Volume 66, Issue 7, July 2026.
Abstract Pediatric oncology drug development remains uniquely challenging due to the rarity and biological heterogeneity of childhood cancers, ethical considerations in trial conduct, and the limited feasibility of large, randomized studies. Despite these barriers, recent years have seen a notable acceleration in the approval of oncology therapies for ...
Ya‐Feng Wen, Xiaoning Wang, Sarandeep Boyanapalli, Lee Anderson, Thao Dang, Guan Xing, Marianna Calvet, Tiffany Hart, Sreeneeranj Kasichayanula, Xiaochen Zhao   +9 more
wiley   +1 more source

Mortality trends and risk factors in advanced stage-2 Human African Trypanosomiasis: A critical appraisal of 23 years of experience in the Democratic Republic of Congo.

PLoS Neglected Tropical Diseases, 2018
We conducted a retrospective study on mortality trends and risk factors in 781 naïve cases of advanced stage-2 sleeping sickness admitted between 1989 and 2012 at the National Reference Center for Human African Trypanosomiasis (HAT), Department of ...
Léon Mbiyangandu Kazumba, Jean-Claude Tshinzobe Kaka, Dieudonné Mumba Ngoyi, Désiré Tshala-Katumbay   +3 more
doaj   +1 more source

Safety and efficacy of hydroxyurea and eflornithine against most blood parasites Babesia and Theileria.

PLoS ONE, 2020
BACKGROUND:The plenteous resistance to and undesirable consequences of the existing antipiroplasmic therapies have emphasized the urgent need for new chemotherapeutics and drug targets for both prophylaxis and chemotherapy.
Gaber El-Saber Batiha, Amany Magdy Beshbishy, Oluyomi Stephen Adeyemi, Eman Nadwa, Eman Rashwan, Naoaki Yokoyama, Ikuo Igarashi   +6 more
doaj   +1 more source

Effects of Synthetic Ligustrazine-Based Chalcone Derivatives on Trypanosoma brucei brucei and Leishmania spp. Promastigotes

Molecules, 2023
Current medication therapy for leishmaniasis and trypanosomiasis remains a major challenge due to its limited efficacy, significant adverse effects, and inaccessibility.
Abdulsalam A. M. Alkhaldi
doaj   +1 more source

A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes

eLife, 2020
Trypanosomes have a trypanothione redox metabolism that provides the reducing equivalents for numerous essential processes, most being mediated by tryparedoxin (Tpx).
Samantha Ebersoll, Marta Bogacz, Lina M Günter, Tobias P Dick, R Luise Krauth-Siegel   +4 more
doaj   +1 more source

Exploring Novel Nitrofuryl‐1,3,4‐Thiadiazole‐Based Derivatives: Design, Synthesis, and Evaluation of In Vitro Leishmanicidal and Trypanocidal Activity

Archiv der Pharmazie, Volume 359, Issue 3, March 2026.
In a series of substituted 1‐[5‐(5‐nitrofuran‐2‐yl)‐1,3,4‐thiadiazol‐2‐yl]piperidine‐4‐carboxamides evaluated for in vitro antileishmanial and antitrypanosomal activity, compound 18 emerged as the most promising derivative, showing submicromolar anti‐parasitic effects targeting diverse Leishmania and Trypanosoma species and acceptable selectivity ...
Alireza Mousavi, Martina Slapničková, Maryam Norouzbahari, Sarah D'Alessandro, Parham Foroumadi, Fariba Peytam, Federica Perego, Eva Doleželová, Zahra Emamgholipour, Maliheh Barazandeh Tehrani, Seyed Esmaeil Sadat‐Ebrahimi, Elahe Hosseinzadeh, Elmira Meghrazi Ahadi, Loghman Firoozpour, Hamidreza Bijanzadeh, Nicoletta Basilico, Alena Zíková, Alireza Foroumadi   +17 more
wiley   +1 more source

Efficacy of Eflornithine Hydrochloride Cream in the Treatment of Melasma: A Randomized, Double‐Blinded, Split‐Face–Controlled Pilot Trial

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Background Melasma treatment remains challenging with variable response to conventional lightening agents. Polyamine inhibition via ornithine decarboxylase 1 (ODC1) may offer an alternative approach, with eflornithine hydrochloride being an established ODC1 inhibitor. Objectives To compare the efficacy and safety of eflornithine hydrochloride 13% cream
Jonathan Yongwei Boey, Xue Ting Ooi, Amanda Kuan, Sai Yee Chuah, Anjali Jhingan, Leah A. Vardy, Steven Thng, Yolanda Gilaberte   +7 more
wiley   +1 more source

Melarsoprol versus eflornithine for treating late-stage Gambian trypanosomiasis in the Republic of the Congo

Bulletin of the World Health Organization, 2006
OBJECTIVE: To compare the effectiveness of melarsoprol and eflornithine in treating late-stage Gambian trypanosomiasis in the Republic of the Congo. METHODS: We analysed the outcomes of death during treatment and relapse within 1 year of discharge for ...
Manica Balasegaram, Steve Harris, Francesco Checchi, Sara Ghorashian, Catherine Hamel, Unni Karunakara   +5 more
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