Results 61 to 70 of about 2,541 (192)

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, Volume 150, Issue 7, Page 990-1015, August 2026.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source

Accelerating Pediatric Oncology Drug Development: Advances in Clinical Pharmacology, Trial Design, Non‐Clinical Evidence, and Regulatory Science

The Journal of Clinical Pharmacology, Volume 66, Issue 7, July 2026.
Abstract Pediatric oncology drug development remains uniquely challenging due to the rarity and biological heterogeneity of childhood cancers, ethical considerations in trial conduct, and the limited feasibility of large, randomized studies. Despite these barriers, recent years have seen a notable acceleration in the approval of oncology therapies for ...
Ya‐Feng Wen, Xiaoning Wang, Sarandeep Boyanapalli, Lee Anderson, Thao Dang, Guan Xing, Marianna Calvet, Tiffany Hart, Sreeneeranj Kasichayanula, Xiaochen Zhao   +9 more
wiley   +1 more source

Image3_Identification of transport systems involved in eflornithine delivery across the blood-brain barrier.JPEG

, 2023
Human African Trypanosomiasis (HAT) is a neglected parasitic disease that continues to persist in sub-Saharan Africa. It is fatal if untreated. The first stage of the disease is associated with the presence of the parasite in the periphery and the second
Christopher P. Watson (15831914), Sarah A. Thomas (9983449), Gayathri Nair Sekhar (15831917)   +2 more
core   +1 more source

Effectiveness and safety of triple-diode laser with or without adjunctive topical eflornithine in female hirsutism

Journal of the Pakistan Medical Association
Objective: To compare the efficacy of triple diode laser with and without topical eflornithine in hair growth reduction. Method: The cross-sectional study was conducted at the outpatient clinic of the Department of Dermatology, Dow University of ...
Sadia Bhatti, Sadaf Ahmed Asim, Tayyaba Iqbal, Madiha Sajid   +3 more
doaj   +1 more source

Exploring Novel Nitrofuryl‐1,3,4‐Thiadiazole‐Based Derivatives: Design, Synthesis, and Evaluation of In Vitro Leishmanicidal and Trypanocidal Activity

Archiv der Pharmazie, Volume 359, Issue 3, March 2026.
In a series of substituted 1‐[5‐(5‐nitrofuran‐2‐yl)‐1,3,4‐thiadiazol‐2‐yl]piperidine‐4‐carboxamides evaluated for in vitro antileishmanial and antitrypanosomal activity, compound 18 emerged as the most promising derivative, showing submicromolar anti‐parasitic effects targeting diverse Leishmania and Trypanosoma species and acceptable selectivity ...
Alireza Mousavi, Martina Slapničková, Maryam Norouzbahari, Sarah D'Alessandro, Parham Foroumadi, Fariba Peytam, Federica Perego, Eva Doleželová, Zahra Emamgholipour, Maliheh Barazandeh Tehrani, Seyed Esmaeil Sadat‐Ebrahimi, Elahe Hosseinzadeh, Elmira Meghrazi Ahadi, Loghman Firoozpour, Hamidreza Bijanzadeh, Nicoletta Basilico, Alena Zíková, Alireza Foroumadi   +17 more
wiley   +1 more source

Short-course eflornithine in Gambian trypanosomiasis: a multicentre randomized controlled trial

Bulletin of the World Health Organization, 2000
OBJECTIVE: A randomized controlled trial was conducted to determine whether 7 days of intravenous eflornithine (100 mg/kg every 6 h) was as effective as the standard 14-day regimen in the treatment of late-stage Trypanosoma brucei gambiense ...
Jacques Pépin, Nzambi Khonde, Faustine Maiso, Félix Doua, Shabbar Jaffar, Stéphane Ngampo, Bokelo Mpia, Dawson Mbulamberi, Felix Kuzoe   +8 more
doaj  

Efficacy of Eflornithine Hydrochloride Cream in the Treatment of Melasma: A Randomized, Double‐Blinded, Split‐Face–Controlled Pilot Trial

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Background Melasma treatment remains challenging with variable response to conventional lightening agents. Polyamine inhibition via ornithine decarboxylase 1 (ODC1) may offer an alternative approach, with eflornithine hydrochloride being an established ODC1 inhibitor. Objectives To compare the efficacy and safety of eflornithine hydrochloride 13% cream
Jonathan Yongwei Boey, Xue Ting Ooi, Amanda Kuan, Sai Yee Chuah, Anjali Jhingan, Leah A. Vardy, Steven Thng, Yolanda Gilaberte   +7 more
wiley   +1 more source

Image5_Identification of transport systems involved in eflornithine delivery across the blood-brain barrier.JPEG

, 2023
Human African Trypanosomiasis (HAT) is a neglected parasitic disease that continues to persist in sub-Saharan Africa. It is fatal if untreated. The first stage of the disease is associated with the presence of the parasite in the periphery and the second
Christopher P. Watson (15831914), Sarah A. Thomas (9983449), Gayathri Nair Sekhar (15831917)   +2 more
core   +1 more source

Image6_Identification of transport systems involved in eflornithine delivery across the blood-brain barrier.JPEG

, 2023
Human African Trypanosomiasis (HAT) is a neglected parasitic disease that continues to persist in sub-Saharan Africa. It is fatal if untreated. The first stage of the disease is associated with the presence of the parasite in the periphery and the second
Christopher P. Watson (15831914), Sarah A. Thomas (9983449), Gayathri Nair Sekhar (15831917)   +2 more
core   +1 more source

Image4_Identification of transport systems involved in eflornithine delivery across the blood-brain barrier.JPEG

, 2023
Human African Trypanosomiasis (HAT) is a neglected parasitic disease that continues to persist in sub-Saharan Africa. It is fatal if untreated. The first stage of the disease is associated with the presence of the parasite in the periphery and the second
Christopher P. Watson (15831914), Sarah A. Thomas (9983449), Gayathri Nair Sekhar (15831917)   +2 more
core   +1 more source