Results 81 to 90 of about 2,541 (192)

Image7_Identification of transport systems involved in eflornithine delivery across the blood-brain barrier.JPEG

, 2023
Human African Trypanosomiasis (HAT) is a neglected parasitic disease that continues to persist in sub-Saharan Africa. It is fatal if untreated. The first stage of the disease is associated with the presence of the parasite in the periphery and the second
Christopher P. Watson (15831914), Sarah A. Thomas (9983449), Gayathri Nair Sekhar (15831917)   +2 more
core   +1 more source

Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy

Advanced Science, Volume 12, Issue 40, October 27, 2025.
Metabolic rewiring in cancer is mapped across glucose, amino acid, lipid, nucleotide, and mitochondrial pathways, with emphasis on immune regulation. The review integrates mechanisms linking these pathways to tumor progression and therapy resistance, and profiles nanomaterial platforms that both deliver therapeutics and actively reprogram ...
Xiaosu Zhou, Ruibing Deng, Zunde Liao, Xiaoyu Huang, Junting Huang, Hanlou Yang, Kam W. Leong, Yiling Zhong   +7 more
wiley   +1 more source

Effets de la difluorométhylornithine après administration intraveineuse et son association avec de l'acéturate de diminazène contre Trypanosoma bruceichez des chiens infectés expérimentalement au Nigeria

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1997
De la difluorométhylornithine (DFMO, eflornithine) a été donnée par voie intraveineuse (lV) à des chiens infectés expérimentalement par Trypanosoma brucei.
B.M. Anene, S.M. Anika, C.C. Chukwu
doaj   +1 more source

Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine Médecins Sans Frontières programmes.

, 2009
This paper describes the effectiveness of first-line regimens for stage 2 human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense infection in nine Médecins Sans Frontières HAT treatment programmes in Angola, Republic of Congo, Sudan and ...
Young, Heather, Raguenaud, Marie-Eve, Balasegaram, Manica, Chappuis, François, Priotto, Gerardo, Checchi, Francesco   +5 more
core   +1 more source

Use of Eflornithine (DFMO) in the Treatment of Early Alzheimer's Disease: A Compassionate Use, Single-Case Study

Frontiers in Aging Neuroscience, 2018
Background: Recent genome-wide association screening (GWAS) studies have linked Alzheimer's disease (AD) neuropathology to gene networks that regulate immune function. Kan et al.
Jessica Alber, Jessica Alber, Kelly McGarry, Richard B. Noto, Peter J. Snyder, Peter J. Snyder, Peter J. Snyder   +6 more
doaj   +1 more source

Trypanosoma brucei eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids [PDF]

, 2014
Amino acid transporters are crucial for parasite survival since the cellular metabolism of parasitic protozoa depends on the uptake of exogenous amino acids.
González Salgado, Amaia, Wirdnam, Corina, Sigel, Erwin, Zilberstein, Dan, Suter, Marianne, Meier, Stefan, Mäser, Pascal, Bütikofer, Peter, Salgado, Amaia González, Mathieu, Christoph, Grotemeyer, Marianne Suter, Inbar, Ehud, Rentsch, Doris, Bütikofer P, Meier S, González Salgado A, Rentsch D, Mäser P, Zilberstein D, Sigel E, Wirdnam C, Grotemeyer MS, Mathieu C, Inbar E   +23 more
core   +1 more source

Kinetoplastida: new therapeutic strategies

Parasite, 2008
New formulations and therapeutic switching of the established drugs, amphotericin B and paromomycin, together with the discovery of miltefosine, have significantly improved the opportunities for treatment of visceral leishmaniasis (VL) chemotherapy ...
Croft S.L.
doaj   +1 more source

A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro [PDF]

, 2013
Recently, the World Health Organization approved the nifurtimox–eflornithine combination therapy for the treatment of human African trypanosomiasis, renewing interest in nitroheterocycle therapies for this and associated diseases.
Smith, Terry K, Rideau, Emeline, Stewart, Gavin, Zhou, Linna, Westwood, Nicholas James, Westwood, Nicholas James; id_orcid, Smith, Terry K; id_orcid   +6 more
core   +1 more source

In silico study and in vitro antileishmanial and antitrypanosomal evaluation of azopyrazoles and azopyrimidines

Pakistan Journal of Pharmaceutical Sciences
Hydrazones 1-6, azo-pyrazoles 7-9 and azo-pyrimidines 10-15 are compounds that exhibit antibacterial activity. The mode of action and structures of these derivatives have been previously confirmed as antibacterial.
Abdulsalam AM Alkhaldi, Phoebe F Lamie, Mohamed A Abdelgawad   +2 more
doaj   +1 more source

Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine Médecins Sans Frontières programmes [PDF]

, 2017
This paper describes the effectiveness of first-line regimens for stage 2 human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense infection in nine Médecins Sans Frontières HAT treatment programmes in Angola, Republic of Congo, Sudan and ...
Young, Heather, Raguenaud, Marie-Eve, Balasegaram, Manica, Chappuis, François, Priotto, Gerardo, Checchi, Francesco   +5 more
core